Singh D N, Nathaniel E J
Anat Rec. 1977 Nov;189(3):413-31. doi: 10.1002/ar.1091890303.
The differentiation of the mitral cell perikaryon in postnatal rat olfactory bulb was studied with the light and electron microscope. At birth the mitral cell was distinguishable and occupied a definitive position in the mitral cell layer. The cell contained a large oval nucleus surrounded by a thin rim of cytoplasm. Ribosomes, free and clustered, were scattered in the cell cytoplasm. Rough endoplasmic reticulum was relatively scarce. The Golgi complexes were made up of stacks of smooth-surfaced cisternae and associated vesicles. In certain cases the Golgi complexes projected into cellular processes. Mitochondria were present in all regions of the cytoplasm and contained well developed cristae. At the end of the first week, the mitral cell had developed significantly in size, and the cytoplasm contained well-developed rough endoplasmic reticulum. The Golgi complexes were made up of several stacks of smooth-surfaced cisternae with the association of vesicles and electron dense bodies. The apical dendrites of mitral cells at this period had increased significantly in length. Subsequently, during the second and third week, the rough endoplasmic reticulum and Golgi complexes became well developed. Associated with the Golgi complexes were electron dense lysosomal bodies. At three weeks and in older cells it was observed that dense lipofuschin granules increased significantly. It is suggested that the mitral cell matures and differentiates earlier than cells in the cerebral cortex.
采用光镜和电镜研究了出生后大鼠嗅球内二尖瓣细胞胞体的分化情况。出生时，二尖瓣细胞即可辨认，并在二尖瓣细胞层中占据特定位置。细胞含有一个大的椭圆形细胞核，周围有一薄层细胞质。核糖体，游离的和成簇的，散在于细胞质中。粗面内质网相对较少。高尔基体由堆叠的光滑表面的扁平囊泡和相关的小泡组成。在某些情况下，高尔基体延伸至细胞突起内。线粒体存在于细胞质的所有区域，且含有发育良好的嵴。在第一周结束时，二尖瓣细胞大小显著增大，细胞质中含有发育良好的粗面内质网。高尔基体由几堆叠的光滑表面的扁平囊泡以及小泡和电子致密体组成。此时二尖瓣细胞的顶端树突长度显著增加。随后，在第二周和第三周期间，粗面内质网和高尔基体发育良好。与高尔基体相关的是电子致密溶酶体。在三周及更老的细胞中观察到致密的脂褐素颗粒显著增加。提示二尖瓣细胞比大脑皮质中的细胞成熟和分化更早。
