Mosley J W, Redeker A G, Feinstone S M, Purcell R H
N Engl J Med. 1977 Jan 13;296(2):75-8. doi: 10.1056/NEJM197701132960204.
We evaluated the causes of 30 episodes of acute viral hepatitis in 13 patients who had multiple attacks. Two (seven per cent) of 30 bouts were caused by hepatitis A virus, and 12 (40%) by hepatitis B virus. No patient, however, had more than one attack with the serologic characteristics of Type A or Type B disease. Thus, there were 16 bouts (53 per cent) not attributable to either of the two recognized hepatitis viruses. None of these "non-A, non-B" episodes, evaluated for infectious mononucleosis and cytomegalovirus infection, could be ascribed to either. From this evidence, therefore, it appears that the clinical syndrome of viral hepatitis is produced not only by the two viruses (hepatitis A virus and hepatitis B virus) recognized since the 1940's but also, in all probability, by two non-A, non-B agents.
我们评估了13例多次发作急性病毒性肝炎患者的30次发作病因。30次发作中，2次（7%）由甲型肝炎病毒引起，12次（40%）由乙型肝炎病毒引起。然而，没有患者出现超过1次具有甲型或乙型疾病血清学特征的发作。因此，有16次发作（53%）不能归因于两种已知的肝炎病毒中的任何一种。对这些“非甲非乙”发作进行传染性单核细胞增多症和巨细胞病毒感染评估，均不能归因于这两种疾病。因此，从这些证据来看，病毒性肝炎的临床综合征似乎不仅由20世纪40年代以来已知的两种病毒（甲型肝炎病毒和乙型肝炎病毒）引起，很可能还由两种非甲非乙病原体引起。
