非甲非乙型输血后肝炎

Non-A, non-B post-transfusion hepatitis.

作者信息

Dienstag J L, Purcell H R, Alter H J, Feinstone S M, Wong D C, Holland P V

出版信息

Lancet. 1977 Mar 12;1(8011):560-2. doi: 10.1016/s0140-6736(77)91996-1.

DOI:10.1016/s0140-6736(77)91996-1

Abstract

To clarify the role of hepatitis-A virus (H.A.V.) in the aetiology of post-transfusion hepatitis unrelated to hepatitis-B virus, we have tested and titred pre-transfusion and convalescent serum samples from 32 patients for antibody to hepatitis-A antigen (anti-HA) by quantitative immune adherence haemagglutination. 12 patients had no detectable anti-HA in either pre-transfusion or late convalescent serum; the other 20 had anti-HA in pretransfusion serum and no significant chance in titre during convalescence. This study excludes H.A.V. as the agent responsible for these cases of post-transfusion hepatitis and supports the existence of "non-A, non-B" hepatitis virus(es).

摘要

为阐明甲型肝炎病毒（H.A.V.）在与乙型肝炎病毒无关的输血后肝炎病因学中的作用，我们采用定量免疫粘附血凝试验，对32例患者输血前和恢复期血清样本进行了甲型肝炎抗原抗体（抗-HA）检测和滴定。12例患者在输血前或恢复期晚期血清中均未检测到抗-HA；另外20例患者输血前血清中有抗-HA，恢复期滴度无显著变化。本研究排除了H.A.V.作为这些输血后肝炎病例的致病原，并支持“非甲非乙”型肝炎病毒的存在。