Kamimura S, Eguchi K, Sekiba K
Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
Acta Med Okayama. 1991 Apr;45(2):101-6. doi: 10.18926/AMO/32183.
Concentrations of tryptophan (free and protein bound) and its metabolites in plasma of maternal vein at delivery, umbilical vein, umbilical artery, neonatal vein and breast milk were determined by high performance liquid chromatography. The plasma levels of tryptophan and most of its metabolites in umbilical vein and artery were significantly higher than those in maternal vein. The concentration of total tryptophan in plasma of neonatal vein showed marked decrease at 24 h after birth in comparison with that at birth, but the total kynurenine concentration was not decreased in plasma of neonatal vein. The colostrum contained a high level of total tryptophan. There were high ratios of free to total tryptophan in colostrum, transitional and mature milk. In the blood, ratios of free to total of tryptophan and kynurenine were kept at constant level throughout the perinatal period.
采用高效液相色谱法测定分娩时母体静脉血、脐静脉血、脐动脉血、新生儿静脉血及母乳中色氨酸（游离及与蛋白质结合）及其代谢产物的浓度。脐静脉和脐动脉血中色氨酸及其大多数代谢产物的血浆水平显著高于母体静脉血。与出生时相比，新生儿静脉血中总色氨酸浓度在出生后24小时显著降低，但新生儿静脉血中总犬尿氨酸浓度并未降低。初乳中总色氨酸含量较高。初乳、过渡乳和成熟乳中游离色氨酸与总色氨酸的比例较高。在血液中，色氨酸和犬尿氨酸的游离与总比例在围产期保持恒定水平。
