van Lee Linde, Cai Shirong, Loy See Ling, Tham Elaine K H, Yap Fabian K P, Godfrey Keith M, Gluckman Peter D, Shek Lynette P C, Teoh Oon Hoe, Goh Daniel Y T, Tan Kok Hian, Chong Yap Seng, Meaney Michael J, Chen Helen, Broekman Birit F P, Chong Mary F F
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore.
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
J Affect Disord. 2018 Jan 1;225:523-529. doi: 10.1016/j.jad.2017.08.069. Epub 2017 Aug 23.
Evidence suggests a relation between plasma tryptophan concentrations and sleep and mental well-being. As no studies have been performed in pregnant women, we studied the relation of plasma tryptophan concentrations during pregnancy with sleep quality, and mood during and after pregnancy.
Pregnant women (n = 572) from the Growing Up in Singapore Towards healthy Outcomes study completed the Pittsburgh Sleep Quality Index (PSQI), the Edinburgh Postnatal Depression Scale (EPDS) and the State-Trait Anxiety Inventory (STAI) at 26-28 weeks gestation and three months post-delivery. Plasma tryptophan concentrations were measured at 26-28 weeks gestation. Poisson regressions estimated prevalence ratios (PR) for the association between tryptophan and poor sleep quality (PSQI global score > 5), probable antenatal depression (EPDS ≥ 15) and probable anxiety (STAI-state ≥ 41) were calculated adjusting for covariates.
Mean plasma tryptophan concentrations was 48.0µmol/L (SD: 8.09). Higher plasma tryptophan concentrations were associated with a lower prevalence of antenatal poor sleep quality adjusting for covariates [PR: 0.88 (95% CI 0.80, 0.97) per 10µmol/L], especially in those participants who also suffered from anxiety symptoms [PR: 0.80 (95% CI 0.67, 0.95)]. No associations were observed between tryptophan concentrations during pregnancy and postnatal sleep quality or mental well-being.
Subjective measures were used to assess sleep and mental well-being.
We observed that higher plasma tryptophan concentrations were associated with a 12% lower prevalence of poor sleep quality during pregnancy, in particular among those with anxiety symptoms. These findings suggest the importance of having adequate tryptophan concentrations during pregnancy.
有证据表明血浆色氨酸浓度与睡眠及心理健康之间存在关联。由于尚未对孕妇进行相关研究，我们研究了孕期血浆色氨酸浓度与睡眠质量以及孕期和产后情绪之间的关系。
来自新加坡成长为健康个体研究的孕妇（n = 572）在妊娠26 - 28周及产后三个月完成了匹兹堡睡眠质量指数（PSQI）、爱丁堡产后抑郁量表（EPDS）和状态 - 特质焦虑量表（STAI）。在妊娠26 - 28周时测量血浆色氨酸浓度。采用泊松回归估计色氨酸与睡眠质量差（PSQI全球评分> 5）、可能的产前抑郁（EPDS≥15）和可能的焦虑（STAI - 状态≥41）之间关联的患病率比值（PR），并对协变量进行调整。
血浆色氨酸平均浓度为48.0µmol/L（标准差：8.09）。调整协变量后，较高的血浆色氨酸浓度与产前睡眠质量差的患病率较低相关[每10µmol/L的PR：0.88（95%可信区间0.80，0.97）]，尤其是在那些也有焦虑症状的参与者中[PR：0.80（95%可信区间0.67，0.95）]。未观察到孕期色氨酸浓度与产后睡眠质量或心理健康之间的关联。
采用主观测量方法评估睡眠和心理健康。
我们观察到较高的血浆色氨酸浓度与孕期睡眠质量差的患病率低12%相关联，特别是在有焦虑症状的人群中。这些发现表明孕期保持充足色氨酸浓度的重要性。
