用于生物正交1,3-偶极环加成反应的长波长光可激活二芳基四唑的发现。
Discovery of long-wavelength photoactivatable diaryltetrazoles for bioorthogonal 1,3-dipolar cycloaddition reactions.
作者信息
Wang Yizhong, Hu Wen J, Song Wenjiao, Lim Reyna K V, Lin Qing
机构信息
Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA.
出版信息
Org Lett. 2008 Sep 4;10(17):3725-8. doi: 10.1021/ol801350r. Epub 2008 Aug 1.
PMID:18671406
Abstract
Several long-wavelength (365 nm) photoactivatable diaryltetrazoles were discovered by screening a series of substituted diaryltetrazoles and subsequently showed excellent reactivity in the photoactivated 1,3-dipolar cycloaddition reactions toward electron-deficient and conjugated alkenes in organic solvents as well as an alkene-containing protein in the aqueous buffer.
摘要
通过筛选一系列取代的二芳基四唑，发现了几种长波长（365 nm）的光可活化二芳基四唑，随后它们在有机溶剂中对缺电子共轭烯烃以及在水性缓冲液中的含烯烃蛋白质的光活化1,3-偶极环加成反应中表现出优异的反应活性。
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