甲状腺激素衍生物3-碘甲腺原氨酸可增加啮齿动物的食物摄入量。
The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents.
作者信息
Dhillo W S, Bewick G A, White N E, Gardiner J V, Thompson E L, Bataveljic A, Murphy K G, Roy D, Patel N A, Scutt J N, Armstrong A, Ghatei M A, Bloom S R
机构信息
Department of Investigative Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
出版信息
Diabetes Obes Metab. 2009 Mar;11(3):251-60. doi: 10.1111/j.1463-1326.2008.00935.x. Epub 2008 Jul 29.
BACKGROUND
The thyroid hormone derivative 3-iodothyronamine (T(1)AM), an endogenous biogenic amine, is a potent agonist of the G protein-coupled trace amine-associated receptor 1 (TAAR1). T(1)AM is present in rat brain, and TAAR1 is expressed in hypothalamic nuclei associated with the regulation of energy homeostasis.
AIM
The aim of this study was to determine the effects of T(1)AM on food intake in rodents.
METHODS
We determined the effect of (i) intraperitoneal (i.p.) administration of T(1)AM on food intake, oxygen consumption (VO(2)) and locomotor activity in mice; (ii) intracerebroventricular (ICV) injection of T(1)AM on food intake in male rats; (iii) c-fos expression following ventricular administration of T(1)AM in male rats; and (iv) direct injection of T(1)AM into the arcuate nucleus (ARC) of male rats on food intake.
RESULTS
(i) T(1)AM (4 nmol/kg) significantly increased food intake following i.p. injection in mice but had no effect on VO(2) or locomotor activity. (ii) ICV administration of T(1)AM (1.2 nmol/kg) significantly increased food intake in male rats. (iii) Intraventricular administration of T(1)AM significantly increased c-fos expression in the ARC of male rats. (iv) Direct administration of T(1)AM (0.12, 0.4 and 1.2 nmol/kg) into the ARC of male rats significantly increased food intake.
CONCLUSION
These data suggest that T(1)AM is an orexigenic factor that may act through the ARC to increase food intake in rodents.
背景
甲状腺激素衍生物3 - 碘甲腺原氨酸（T(1)AM）是一种内源性生物胺，是G蛋白偶联的痕量胺相关受体1（TAAR1）的强效激动剂。T(1)AM存在于大鼠脑中，且TAAR1在下丘脑核中表达，这些核与能量稳态调节相关。
目的
本研究旨在确定T(1)AM对啮齿动物食物摄取的影响。
方法
我们测定了：（i）腹腔注射T(1)AM对小鼠食物摄取、耗氧量（VO(2)）和运动活性的影响；（ii）脑室内注射T(1)AM对雄性大鼠食物摄取的影响；（iii）脑室注射T(1)AM后雄性大鼠中c - fos的表达；以及（iv）直接向雄性大鼠弓状核（ARC）注射T(1)AM对食物摄取的影响。
结果
（i）腹腔注射T(1)AM（4 nmol/kg）后，小鼠的食物摄取显著增加，但对VO(2)或运动活性无影响。（ii）脑室内注射T(1)AM（1.2 nmol/kg）显著增加雄性大鼠的食物摄取。（iii）脑室注射T(1)AM显著增加雄性大鼠ARC中c - fos的表达。（iv）直接向雄性大鼠ARC注射T(1)AM（0.12、0.4和1.2 nmol/kg）显著增加食物摄取。
结论
这些数据表明，T(1)AM是一种食欲促进因子，可能通过ARC起作用以增加啮齿动物的食物摄取。
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