Berntsen Erik Magnus, Samuelsen Petter, Lagopoulos Jim, Rasmussen Inge-André, Håberg Asta Kristine, Haraldseth Olav
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Neurol Res. 2008 Nov;30(9):968-73. doi: 10.1179/016164108X323753. Epub 2008 Jul 30.
The aim of this study was to establish a robust set of motor tasks that could be used to functionally delineate the motor cortex with blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) at 3 T and produce precise functional maps for pre-operative planning and functional neuronavigation.
Twelve male and four female control subjects were recruited for this study which examined six different motor tasks. Finger-, tongue-, lip- and toe-movements, as well as isometric upper arm- and thigh-contraction tasks were conducted during separate scans on a 3 T MRI scanner. Furthermore, patients that previously had undergone similar motor tasks were reviewed, to evaluate whether this set of tasks was able to be adopted for use in a population of patients with brain lesions.
The results of this study indicated that the finger-, toe- and tongue-motor tasks were the most robust in identifying their respective primary motor area. Moreover, all three tasks activated regions at regular intervals along the convexity of the hemisphere, making it possible to functionally delineate the primary motor cortex in both healthy subjects and patients.
The motor tasks described in this study (toe, finger and tongue) were effective at localizing the primary motor cortex for the purposes of neurosurgical planning. These three tasks produced the highest success rate and resulted in activations at regular intervals along the convexity of the hemisphere, allowing the delineation of the entire motor strip even in the presence of edema and anatomical distortions.
本研究的目的是建立一套可靠的运动任务，可用于在3T场强下通过血氧水平依赖性功能磁共振成像（BOLD fMRI）对运动皮层进行功能划分，并为术前规划和功能神经导航生成精确的功能图谱。
招募了12名男性和4名女性对照受试者参与本研究，该研究考察了六种不同的运动任务。在3T MRI扫描仪上进行单独扫描时，分别进行手指、舌头、嘴唇和脚趾运动，以及上臂和大腿的等长收缩任务。此外，对先前进行过类似运动任务的患者进行了回顾，以评估这组任务是否能够应用于有脑损伤的患者群体。
本研究结果表明，手指、脚趾和舌头运动任务在识别各自的初级运动区方面最为可靠。此外，所有这三项任务均沿半球凸面以规则间隔激活区域，从而有可能在健康受试者和患者中对初级运动皮层进行功能划分。
本研究中描述的运动任务（脚趾、手指和舌头）在为神经外科手术规划定位初级运动皮层方面是有效的。这三项任务成功率最高，并沿半球凸面以规则间隔产生激活，即使在存在水肿和解剖结构变形的情况下也能勾勒出整个运动带。
