Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy.
Prev Med. 2008 Oct;47(4):422-6. doi: 10.1016/j.ypmed.2008.06.020. Epub 2008 Jul 11.
Maintaining or increasing physical activity in late-middle age has been shown to be associated with a reduction in mortality. The aim of the present study was to explore the relationship between regular walking and the risk of all-cause death in a large population of frail and very old people living in community.
We analyzed data from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE study), a prospective cohort study that collected data on all subjects aged 80 year and older living in a mountain community. Baseline assessments of participants started in December 2003 and were completed in September 2004. All subjects were followed-up for 24 months. To the purpose of this study we selected all subjects without impairment in the activities of daily living (n=248). The main outcome measure was the relative hazard ratio of death over two years of follow-up for different levels of walking activity.
During a mean follow-up time of 24 months from baseline assessment, 30 subjects (12%) died. There was an uneven distribution of the risk. After adjusting for age, gender and other possible risk factors of death (functional and cognitive disability, congestive heart failure, hypertension, osteoarthritis, depression, number of medications, body mass index, cholesterol and reactive C protein) subjects walking 1 h or more per day were less likely to die compared to participants walking less than 1 h per day (RR, 0.36; 95% CI 0.12-0.98).
Our results obtained from a representative sample of very old and frail elderly subjects expand the knowledge that high levels of walking activity are associated with better survival.
多项研究表明，中老年人保持或增加身体活动与降低死亡率有关。本研究旨在探讨在一个居住在社区的大量虚弱和非常老的人群中，经常散步与全因死亡风险之间的关系。
我们分析了 Sirente 地理区域（ilSIRENTE 研究）衰老和长寿研究的数据，这是一项前瞻性队列研究，收集了居住在山区社区的所有 80 岁及以上人群的数据。参与者的基线评估于 2003 年 12 月开始，并于 2004 年 9 月完成。所有参与者均随访 24 个月。为了进行这项研究，我们选择了所有没有日常生活活动能力受损的参与者（n=248）。主要观察指标是不同步行活动水平下两年随访期间死亡的相对危险比。
在从基线评估开始的 24 个月的平均随访期间，有 30 名受试者（12%）死亡。风险分布不均。在调整年龄、性别和其他可能的死亡危险因素（功能和认知障碍、充血性心力衰竭、高血压、骨关节炎、抑郁、用药数量、体重指数、胆固醇和反应蛋白）后，每天步行 1 小时或以上的受试者与每天步行不足 1 小时的受试者相比，死亡的可能性较小（RR，0.36；95%CI 0.12-0.98）。
我们从非常老和虚弱的老年受试者的代表性样本中获得的结果扩展了知识，即高水平的步行活动与更好的生存相关。
