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哥斯达黎加老年人肥胖与死亡率的关系:一项队列研究。

Association between obesity and mortality in the Costa Rican elderly: a cohort study.

机构信息

Health Research Institute, University of Costa Rica, San Pedro, Costa Rica.

Human Nutrition Department, University of Costa Rica, San Pedro, Costa Rica.

出版信息

BMC Public Health. 2022 May 18;22(1):1007. doi: 10.1186/s12889-022-13381-9.

Abstract

BACKGROUND

Costa Rica, along with other Latin American countries, is undergoing population aging, with an increase in the prevalence of chronic conditions, many of them resulting from a growing prevalence of obesity. As a result of the demographic and epidemiological transitions, the causes of morbidity and mortality have changed from communicable to non-communicable diseases. An increase in overweight and obesity is hypothesized to be related to premature mortality. This study assesses the association between obesity and both all-cause and cardiovascular mortality in a Costa Rican elderly population.

METHODS

This is a secondary data analysis of the Costa Rican Longevity and Healthy Aging Study (CRELES, for its Spanish acronym), a longitudinal nationally representative cohort study of health and life-course experiences of the Costa Rican elderly. A baseline (n = 2827) and two subsequent 2-year follow-up interviews were conducted. Data analyses include descriptive statistics and survival models. Cox and Gompertz distributions were used to model general mortality and cardiovascular mortality as a function of obesity and controlling for confounders. Anthropometric measures used were Body Mass Index (BMI) and Waist Circumference (WC).

RESULTS

Each one-unit increment in BMI was significantly associated to a 3,1% (p < 0.001) and 2,6% (p = 0.021) increment in general and cardiovascular mortality respectively. Each one-unit increment in WC was significantly associated with a 0,8% (p = 0.006) increment in general mortality, whereas WC was not significantly associated with cardiovascular mortality.

CONCLUSIONS

Obesity is associated with mortality in the Costa Rican elderly. This association is strongest between obesity and all-cause mortality. As general obesity increases, all-cause and cardiovascular mortality also increase in this population. Similarly, as central obesity increases, all-cause mortality increases. Policies aimed at preventing obesity and chronic conditions are warranted for a better survival in this population.

摘要

背景

哥斯达黎加与其他拉丁美洲国家一样,正经历人口老龄化,慢性疾病的患病率上升,其中许多疾病是由于肥胖患病率的增长而导致的。由于人口和流行病学的转变,发病率和死亡率的原因已经从传染病转变为非传染性疾病。超重和肥胖的增加被认为与过早死亡有关。本研究评估了哥斯达黎加老年人群中肥胖与全因和心血管疾病死亡率之间的关系。

方法

这是对哥斯达黎加长寿与健康老龄化研究(CRELES)的二次数据分析,这是一项对哥斯达黎加老年人健康和生命历程经历的全国代表性纵向队列研究。进行了基线(n=2827)和随后的两次 2 年随访访谈。数据分析包括描述性统计和生存模型。Cox 和 Gompertz 分布被用于肥胖和控制混杂因素的情况下,对一般死亡率和心血管疾病死亡率进行建模。使用的人体测量指标是体重指数(BMI)和腰围(WC)。

结果

BMI 每增加一个单位,与一般死亡率分别显著增加 3.1%(p<0.001)和 2.6%(p=0.021),与心血管疾病死亡率分别显著增加 0.8%(p=0.006)。WC 每增加一个单位,与一般死亡率显著相关,而 WC 与心血管疾病死亡率无显著相关性。

结论

肥胖与哥斯达黎加老年人的死亡率有关。这种关联在肥胖与全因死亡率之间最强。随着一般肥胖的增加,该人群的全因和心血管疾病死亡率也会增加。同样,随着中心性肥胖的增加,全因死亡率也会增加。为了提高该人群的生存率,有必要制定预防肥胖和慢性病的政策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee4/9118765/463475234ce5/12889_2022_13381_Fig1_HTML.jpg

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