Rak Malgorzata, Zeng Xiaomei, Brière Jean-Jacques, Tzagoloff Alexander
Department of Biological Sciences, Columbia University New York, NY 10027, USA.
Biochim Biophys Acta. 2009 Jan;1793(1):108-16. doi: 10.1016/j.bbamcr.2008.07.001. Epub 2008 Jul 11.
Respiratory deficient mutants of Saccharomyces cerevisiae have been instrumental in identifying an increasing number of nuclear gene products that promote pre- and post-translational steps of the pathway responsible for biogenesis of the mitochondrial ATP synthase. In this article we have attempted to marshal current information about the functions of such accessory factors and the roles they play in expression and assembly of the mitochondrially encoded subunits of the ATP synthase. We also discuss evidence that the ATP synthase may be built up from three separate modules corresponding to the F1 ATPase, the stator and F0.
酿酒酵母的呼吸缺陷型突变体有助于鉴定越来越多的核基因产物,这些产物促进了负责线粒体ATP合酶生物合成的途径的翻译前和翻译后步骤。在本文中,我们试图整理有关此类辅助因子功能及其在ATP合酶线粒体编码亚基的表达和组装中所起作用的当前信息。我们还讨论了证据,表明ATP合酶可能由对应于F1 ATP酶、定子和F0的三个独立模块组成。