Nosanchuk Joshua D, Gacser Attila
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Microbes Infect. 2008 Jul;10(9):973-7. doi: 10.1016/j.micinf.2008.07.011. Epub 2008 Jul 10.
Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.
荚膜组织胞浆菌是全球侵袭性真菌性肺部疾病最常见的病因。荚膜组织胞浆菌与宿主的相互作用是一个复杂、动态的过程。严重疾病最常发生在免疫功能受损的个体中,并且医学上免疫调节剂使用的增加揭示了潜伏性组织胞浆菌病患者发生疾病再激活的重大风险。幸运的是,有完善的分子工具和优良的动物模型用于研究荚膜组织胞浆菌的毒力,并且关于这种真菌的发病机制最近已经取得了许多进展,这将提高我们对抗疾病的能力。