Li Tian-Hang, Liu Ling, Hou Ya-Yi, Shen Su-Nan, Wang Ting-Ting
Immunology and Reproduction Biology Lab, Medical School of Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, P. R. China.
Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu, P. R. China.
Gastroenterol Rep (Oxf). 2019 Jul 10;7(5):312-321. doi: 10.1093/gastro/goz028. eCollection 2019 Oct.
C-type lectin receptors (CLRs) are powerful pattern-recognition receptors that discern 'self' and 'non-self' in our body and protect us from invasive pathogens by mediating immune recognition and response. The gastrointestinal tract is very important for the maintenance of homeostasis; it is the largest shelter for the billions of microorganisms in the body and CLRs play a crucial regulatory role in this system. This study focuses on several CLRs, including Dectin-1, Dectin-2, Dectin-3 and Mincle. We summarize the roles of CLRs in maintaining gastrointestinal immune-system homeostasis, especially their functions in mediating immune recognition and responses in the gut, discuss their relationships to some diseases, highlight the significance of CLR-mediated sensing of microbial and non-microbial compounds in the gut immune system and identify new therapeutic targets.
C型凝集素受体（CLRs）是强大的模式识别受体，可在我们体内辨别“自身”和“非自身”，并通过介导免疫识别和反应来保护我们免受入侵病原体的侵害。胃肠道对于维持体内平衡非常重要；它是体内数十亿微生物的最大庇护所，而CLRs在这个系统中发挥着关键的调节作用。本研究聚焦于几种CLRs，包括Dectin-1、Dectin-2、Dectin-3和Mincle。我们总结了CLRs在维持胃肠道免疫系统平衡中的作用，特别是它们在介导肠道免疫识别和反应中的功能，讨论它们与某些疾病的关系，强调CLR介导的肠道免疫系统中对微生物和非微生物化合物感知的重要性，并确定新的治疗靶点。
