Drummond P D
Psychology Section, Murdoch University, Murdoch, Western Australia.
Am J Ophthalmol. 1991 Aug 15;112(2):195-9. doi: 10.1016/s0002-9394(14)76701-7.
The aim of this study was to investigate variables that influence the degree of pupillary constriction to dilute pilocarpine eyedrops in healthy control subjects. The pupillary response to 50 microliter of pilocarpine 0.0625% in darkness, dim light, and bright light was measured photographically in 15 healthy adults. Constriction to pilocarpine was greater in darkness and in dim light than in bright light, indicating that the pupillary-light reflex masked the constrictive effect of pilocarpine. In ten other subjects pupillary constriction to 50 microliters of pilocarpine 0.04%, and to 50 and 100 microliters of pilocarpine 0.0625%, was measured on separate occasions. Pupillary constriction increased in proportion to the volume and concentration of pilocarpine. Data for pupillary constriction to 50 microliters of pilocarpine 0.0625% in dim light were determined in all 25 subjects.
本研究的目的是调查影响健康对照受试者对稀释毛果芸香碱滴眼液瞳孔收缩程度的变量。对15名健康成年人在黑暗、暗光和强光条件下，以摄影方式测量其对50微升0.0625%毛果芸香碱的瞳孔反应。毛果芸香碱引起的收缩在黑暗和暗光条件下比在强光条件下更明显，这表明瞳孔光反射掩盖了毛果芸香碱的收缩作用。在另外10名受试者中，分别测量了他们对50微升0.04%毛果芸香碱以及对50微升和100微升0.0625%毛果芸香碱的瞳孔收缩情况。瞳孔收缩与毛果芸香碱的体积和浓度成正比。在所有25名受试者中测定了暗光下对50微升0.0625%毛果芸香碱的瞳孔收缩数据。
