File R R, Patton T F
Arch Ophthalmol. 1980 Jan;98(1):112-5. doi: 10.1001/archopht.1980.01020030114010.
Previous studies with use of animal models have shown that, for topically applied ophthalmic drugs, the fraction of dose absorbed into the eye is increased as the volume in which the drug is instilled is decreased. Such findings have not previously been confirmed in humans. In the present study, the miotic response to instilled doses of 20 and 50 microL of 0.5% pilocarpine hydrochloride was compared in ten adult human volunteers. Although the 20-microL drop represents a substantial dosage reduction, the miotic response was essentially equivalent to that obtained with the 50-microL drop. These findings imply that, due to the large drainage loss of topically applied ophthalmic drugs, volumes delivered by commerical ophthalmic droppers may in some cases be larger than required to achieve the desired response.
以往使用动物模型的研究表明，对于局部应用的眼科药物，随着滴入药物的体积减小，吸收进入眼内的剂量分数会增加。此前这些发现尚未在人类中得到证实。在本研究中，对10名成年人类志愿者滴入20微升和50微升0.5%盐酸毛果芸香碱剂量后的缩瞳反应进行了比较。尽管20微升的滴剂代表了剂量的大幅减少，但缩瞳反应与50微升滴剂所获得的反应基本相同。这些发现意味着，由于局部应用的眼科药物引流损失较大，在某些情况下，商用眼科滴管输送的体积可能大于达到所需反应所需的体积。
