LoGrasso Philip, Kamenecka Theodore
Department of Molecular Therapeutics and Drug Discovery, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458, USA.
Mini Rev Med Chem. 2008 Jul;8(8):755-66. doi: 10.2174/138955708784912120.
Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.
c-Jun氨基末端激酶（JNK）抑制剂有许多潜在的治疗适应症，范围从神经退行性疾病到代谢紊乱、炎症、心血管疾病和癌症。本综述将重点介绍生物抑制剂，如JNK相互作用蛋白（JIP），以及来自各种结构类别的小分子抑制剂，包括氨基嘧啶和吲唑。
