García María Jesús, Martínez-Martos José Manuel, Mayas María Dolores, Carrera María Pilar, De la Chica Susana, Cortés Pedro, Ramírez-Expósito María Jesús
Department of Health Sciences, Physiology, Faculty of Experimental and Health Sciences, University of Jaén, Campus Universitario Las Lagunillas, Jaén, Spain.
Med Chem. 2008 Jul;4(4):336-47. doi: 10.2174/157340608784872271.
The hypothalamus-pituitary-adrenal axis (HPA) participates in the maintenance of cardiovascular functions and in the control of blood pressure. By other hand, it is known that blood pressure regulation and HPA activity are affected by sex hormones. The aim of the present work is to analyze the influence of estradiol and progesterone on renin-angiotensin system (RAS)-regulating aminopeptidase A, aminopeptidase B and aminopeptidase N activities and vasopressin-degrading activity in the HPA axis of ovariectomized mice and ovariectomized mice treated subscutaneously with different doses of estradiol and progesterone. Our data suggest that in female mice, estradiol and progesterone influence RAS-regulating and vasopressin-degrading activities at different levels of the HPA axis.
下丘脑-垂体-肾上腺轴（HPA）参与心血管功能的维持和血压的控制。另一方面，已知血压调节和HPA活性受性激素影响。本研究的目的是分析雌二醇和孕酮对去卵巢小鼠以及皮下注射不同剂量雌二醇和孕酮的去卵巢小鼠HPA轴中肾素-血管紧张素系统（RAS）调节的氨肽酶A、氨肽酶B和氨肽酶N活性以及血管加压素降解活性的影响。我们的数据表明，在雌性小鼠中，雌二醇和孕酮在HPA轴的不同水平影响RAS调节和血管加压素降解活性。
