Passacquale Gabriella, Tiberti Sergio, Ferri Claudio, Desideri Giovambattista
Clinical and Basic Science Research Centre, Cardiovascular Unit, Department of Medical Science, IRCCS San Raffaele, Rome, Italy.
Curr Pharm Des. 2008;14(18):1753-60. doi: 10.2174/138161208784746725.
Atherosclerotic plaque plays a crucial role for the development of ischaemic diseases and, therefore, its early diagnosis and feature can help to reduce the incidence of cardiovascular events. Detection of early atherogenesis and characterization of plaque feature are the major end-points of research in cardiovascular imaging. Different techniques have been proposed as instrument for morphological and functional study of vascular walls. The purpose of this review is to underline the possibility of in vivo detecting the different stages of atherogenesis by using imaging techniques as well as their relationship with other risk factors in an attempt to assess the meaning of vascular lesions. Very promising results seem to emerge by the analysis of the literature on the subject, although different patterns are yet to be clarified.
动脉粥样硬化斑块在缺血性疾病的发展中起着关键作用,因此,其早期诊断和特征有助于降低心血管事件的发生率。早期动脉粥样硬化的检测和斑块特征的表征是心血管成像研究的主要终点。已经提出了不同的技术作为血管壁形态和功能研究的工具。本综述的目的是强调通过使用成像技术在体内检测动脉粥样硬化不同阶段的可能性,以及它们与其他危险因素的关系,试图评估血管病变的意义。尽管不同的模式尚待阐明,但对该主题文献的分析似乎产生了非常有前景的结果。