Kataoka Yu, Nicholls Stephen J
South Australian Health & Medical Research Institute, University of Adelaide, Adelaide, SA, 5000, Australia.
Expert Rev Cardiovasc Ther. 2014 Dec;12(12):1471-89. doi: 10.1586/14779072.2014.975210. Epub 2014 Oct 30.
Obesity is becoming a major health issue in the world due to sedentary lifestyles and increasing intake of Western diets. Obesity is associated with metabolic abnormalities and atherosclerotic cardiovascular diseases. Adipose tissue has been increasingly considered to play a critical role in inducing metabolic disturbances and promoting atherogenesis. Arterial wall imaging permits direct visualization of atheroma burden in various vascular beds. In addition, recent advances in imaging technology help characterize components, microstructures and functional features of atherosclerotic plaques. These imaging modalities have contributed to elucidating factors associated with atherosclerosis in obese patients. Also, it provides opportunities to evaluate the effect of novel therapies on plaques in the setting of obesity. The findings of recent imaging studies and the clinical implications will be reviewed.
由于久坐不动的生活方式以及西方饮食摄入量的增加，肥胖正成为全球主要的健康问题。肥胖与代谢异常和动脉粥样硬化性心血管疾病相关。脂肪组织越来越被认为在引发代谢紊乱和促进动脉粥样硬化形成中起关键作用。动脉壁成像能够直接观察不同血管床中的动脉粥样硬化斑块负荷。此外，成像技术的最新进展有助于表征动脉粥样硬化斑块的成分、微观结构和功能特征。这些成像方式有助于阐明肥胖患者动脉粥样硬化的相关因素。同时，它也为评估肥胖情况下新疗法对斑块的效果提供了机会。本文将综述近期成像研究的结果及其临床意义。
