Shen Y, Li C G, Zhou S F, Pang E C K, Story D F, Xue C C L
The RMIT Chinese Medicine Research Group, School of Health Sciences, RMIT University, Victoria, Australia.
Curr Med Chem. 2008;15(16):1616-27. doi: 10.2174/092986708784911515.
Flos Magnoliae (FM, Chinese name: Xin-yi) is one of the most commonly used Chinese medicinal herbs. It has a long history of clinical use for managing rhinitis, sinusitis and headache. More than 20 different FM species have been used clinically, which makes species identification and evaluation of pharmacological effects of individual chemical ingredients difficult. In this review, we have summarized the current knowledge on FM phytochemistry and its bioactivity activities. The bioactive compounds in FM include both lipid and water-soluble components. More than 90% of the essential components of FM species are terpenoids, including monoterpenes and sesquiterpenes. Lignans and neolignans including tetrahydrofurofuran, tetrahydrofuran and aryltetralin are also present in FM species. A small number of water-soluble compounds have been isolated from Magnolia flower buds, including a benzylisoquinoline alkaloid magnoflorine, an ester ethyl-E-p-hydroxyl-cinnamate and a flavonoid biondnoid. A wide range of pharmacological actions of FM have been reported, including anti-allergy, anti-inflammation and anti-microbial activity. The structure-activity relationship analysis revealed the influence of methylation at position 5 on the 3,7-dioxabicyclo-(3,3,0)-octane backbone of six lignans in antagonistic activities against platelet-activating factor. In addition, the trans stereoisomer fargesin had a much lower bioactivity than the cis stereoisomer demethoxyaschantin. Recent studies have been directed towards the isolation of other bioactive compounds. Further studies on FM may help to develop new anti-inflammatory and anti-allergic drugs.
辛夷是最常用的中药材之一。其在治疗鼻炎、鼻窦炎和头痛方面有着悠久的临床应用历史。临床上使用过20多种不同的辛夷品种，这使得物种鉴定以及对单个化学成分药理作用的评估变得困难。在本综述中，我们总结了目前关于辛夷植物化学及其生物活性的知识。辛夷中的生物活性化合物包括脂溶性和水溶性成分。辛夷品种中超过90%的主要成分是萜类化合物，包括单萜和倍半萜。木脂素和新木脂素，包括四氢呋喃并呋喃、四氢呋喃和芳基四氢萘也存在于辛夷品种中。从辛夷花蕾中分离出了少量水溶性化合物，包括苄基异喹啉生物碱木兰碱、酯类化合物乙基 -E-对羟基肉桂酸酯和一种黄酮类化合物。已报道辛夷具有广泛的药理作用，包括抗过敏、抗炎和抗菌活性。结构 - 活性关系分析揭示了六个木脂素在3,7 - 二氧杂双环-(3,3,0)-辛烷骨架上5位甲基化对其拮抗血小板活化因子活性的影响。此外，反式立体异构体细辛脂素的生物活性远低于顺式立体异构体去甲氧基细辛脂素。最近的研究致力于分离其他生物活性化合物。对辛夷的进一步研究可能有助于开发新的抗炎和抗过敏药物。
