Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, Uttar Pradesh, India.
Recent Adv Inflamm Allergy Drug Discov. 2024;18(2):79-89. doi: 10.2174/0127722708286664240429093913.
Flos Magnoliae is one of the important medicinal plants in different traditional medicine, including Chinese herbal medicine. Lignans and neolignans, including tetrahydrofurofuran, tetrahydrofuran, and aryltetralin, are present in the Flos Magnoliae species. A wide range of pharmacological activity of Flos Magnoliae has been reported in medicine. Fargesin has been isolated from and it is a lignan-class phytochemical. Fargesin has numerous pharmacological activities in medicine, including its effectiveness on lipid and glucose metabolism, oxidative stress, myocardial apoptosis, etc. In the present work, we have summarized the detailed scientific information of fargesin concerning its medicinal properties and pharmacological activities. Numerous biological and chemical aspects of fargesin are discussed here, including the detailed pharmacological activities and analytical aspects of fargesin. In this review, we have also compiled analytical data on fargesin based on available scientific literature. Ethnopharmacological information on fargesin was gathered by a literature survey on PubMed, Science Direct, Google, and Scopus using the terms fargesin, Flos Magnoliae, phytochemical, and herbal medicine. The present review paper compiled the scientific data on fargesin in medicine for its pharmacological activities and analytical aspects in a very concise manner with proper citations. The present work signified the biological importance of fargesin in medicine due to its significant impact on bone disorders, lung injury, colon cancer, atherosclerosis, neurological disorders, ischemia, sars-cov-2, allergy, lipid and glucose metabolism, melanin synthesis, and different classes of enzymes. Furthermore, fargesin also has anti-inflammatory, antihypertensive, antiprotozoal, antimycobacterial, and antifeedant activity. However, analytical methods used for the separation, identification and isolation of fargesin in different biological and non-biological samples were also covered in the present review. The present work revealed the pharmacological activities and analytical aspects of fargesin in medicine and other allied health sectors.
桂花是不同传统医学中重要的药用植物之一，包括中草药。厚朴属植物中存在木脂素和新木脂素，包括四氢呋喃、四氢呋喃和芳基四氢萘。桂花在医学上具有广泛的药理活性。法格辛已从厚朴中分离出来，它是一种木脂素类植物化学物质。法格辛在医学上具有许多药理活性，包括对脂质和葡萄糖代谢、氧化应激、心肌细胞凋亡等的有效性。在本工作中，我们总结了法格辛的详细科学信息，包括其药用特性和药理活性。这里讨论了法格辛的许多生物和化学方面，包括法格辛的详细药理活性和分析方面。在本综述中，我们还根据现有科学文献编译了法格辛的分析数据。通过在 PubMed、Science Direct、Google 和 Scopus 上使用法格辛、桂花、植物化学物质和草药等术语对法格辛进行文献调查，收集了法格辛的民族药理学信息。本综述论文以简洁的方式编译了医学中法格辛的科学数据，用于其药理活性和分析方面，并附有适当的引文。由于法格辛对骨骼疾病、肺损伤、结肠癌、动脉粥样硬化、神经紊乱、缺血、SARS-CoV-2、过敏、脂质和葡萄糖代谢、黑色素合成以及不同类别的酶的显著影响，本工作标志着法格辛在医学中的生物学重要性。此外，法格辛还具有抗炎、降压、抗原生动物、抗分枝杆菌和抗食作用。然而，本综述还涵盖了用于分离、鉴定和分离不同生物和非生物样品中法格辛的分析方法。本工作揭示了法格辛在医学和其他相关健康领域的药理活性和分析方面。
