Gupta Achla, Heimann Andrea S, Gomes Ivone, Devi Lakshmi A
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Comb Chem High Throughput Screen. 2008 Jul;11(6):463-7. doi: 10.2174/138620708784911465.
Antibodies are components of the body's humoral immune system that are generated in response to foreign pathogens. Modern biomedical research has employed these very specific and efficient molecules designed by nature in the diagnosis of diseases, localization of gene products as well as in the rapid screening of targets for drug discovery and testing. In addition, the introduction of antibodies with fluorescent or enzymatic tags has significantly contributed to advances in imaging and microarray technology, which are revolutionizing disease research and the search for effective therapeutics. More recently antibodies have been used in the isolation of dimeric G protein-coupled receptor (GPCR) complexes. In this review, we discuss antibodies as powerful research tools for studying GPCRs, and their potential to be developed as drugs themselves.
抗体是机体体液免疫系统的组成部分，是针对外来病原体产生的。现代生物医学研究利用了这些由自然设计的非常特异且高效的分子，用于疾病诊断、基因产物定位以及药物发现和测试靶点的快速筛选。此外，带有荧光或酶标签的抗体的引入极大地推动了成像和微阵列技术的进步，这些技术正在彻底改变疾病研究和有效治疗方法的探索。最近，抗体已被用于分离二聚体G蛋白偶联受体（GPCR）复合物。在本综述中，我们讨论抗体作为研究GPCR的强大研究工具，以及它们自身作为药物开发的潜力。
