Riggs Ryan M, Duran E Hakan, Baker Margaret W, Kimble Thomas D, Hobeika Elie, Yin Larry, Matos-Bodden Lira, Leader Ben, Stadtmauer Laurel
Department of Obstetrics and Gynecology, Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Am J Obstet Gynecol. 2008 Aug;199(2):202.e1-8. doi: 10.1016/j.ajog.2008.05.004.
The objective of this study was to evaluate basal anti-Müllerian hormone as a marker for ovarian responsiveness to fertility treatment.
Frozen basal menstrual cycle day 3 serum samples were evaluated retrospectively for anti-Müllerian hormone, inhibin B, and follicle-stimulating hormone levels in 123 in vitro fertilization cycles (93 patients) and compared with in vitro fertilization records.
Anti-Müllerian hormone values correlated the best with the number of retrieved oocytes (r = 0.539; P < .001) relative to age (r = -0.323; P < .01), follicle-stimulating hormone (r = -0.317; P < .01), inhibin B (P > .05), luteinizing hormone (P > .05), and estradiol (r = -0.190; P < .05). Receiver operating characteristic curve analysis demonstrated that, for the prediction of <4 oocytes retrieved, anti-Müllerian hormone had the largest area under the curve (AUC = 0.81; P = .0001) relative to age (r = 0.74; P = .005), follicle-stimulating hormone (0.71; P = .02), inhibin B (0.66; P = .03), and estradiol (0.54; P > .05). Similarly, for the prediction of >or=15 retrieved oocytes, anti-Müllerian hormone had the largest area under the curve (0.80; P = .0001) relative to age (0.63; P = .02), follicle-stimulating hormone (0.64; P = .005), inhibin B (r = 0.57; P > .05), and estradiol (0.58; P > .05).
Anti-Müllerian hormone correlates better than age, follicle-stimulating hormone, luteinizing hormone, inhibin B, and estradiol with the number of retrieved oocytes. Receiver operating characteristic curves estimated that anti-Müllerian hormone accurately predicts ovarian responsiveness to controlled ovarian stimulation with high sensitivity and specificity.
本研究的目的是评估基础抗苗勒管激素作为卵巢对生育治疗反应性的标志物。
回顾性评估123个体外受精周期（93例患者）中冷冻的基础月经周期第3天血清样本的抗苗勒管激素、抑制素B和促卵泡激素水平，并与体外受精记录进行比较。
相对于年龄（r = -0.323；P <.01）、促卵泡激素（r = -0.317；P <.01）、抑制素B（P >.05）、黄体生成素（P >.05）和雌二醇（r = -0.190；P <.05），抗苗勒管激素值与回收的卵母细胞数量相关性最好（r = 0.539；P <.001）。受试者工作特征曲线分析表明，对于预测回收卵母细胞<4个，抗苗勒管激素相对于年龄（r = 0.74；P =.005）、促卵泡激素（0.71；P =.02）、抑制素B（0.66；P =.03）和雌二醇（0.54；P >.05）的曲线下面积最大（AUC = 0.81；P =.0001）。同样，对于预测回收卵母细胞≥15个，抗苗勒管激素相对于年龄（0.63；P =.02）、促卵泡激素（0.64；P =.005）、抑制素B（r = 0.57；P >.05）和雌二醇（0.58；P >.05）的曲线下面积最大（0.80；P =.0001）。
抗苗勒管激素与回收的卵母细胞数量的相关性优于年龄、促卵泡激素、黄体生成素、抑制素B和雌二醇。受试者工作特征曲线估计，抗苗勒管激素能以高敏感性和特异性准确预测卵巢对控制性卵巢刺激的反应性。
