A new multi-gram synthetic route to labeling precursors for the D(2/3) PET agent 18F-fallypride.
作者信息
Kim Kwangho, Miller Nicole R, Sulikowski Gary A, Lindsley Craig W
机构信息
Department of Chemistry and Pharmacology, Institute of Chemical Biology, Vanderbilt University, 802 Robinson Research Building, Nashville, TN 37235-1822, USA.
出版信息
Bioorg Med Chem Lett. 2008 Aug 15;18(16):4467-9. doi: 10.1016/j.bmcl.2008.07.065. Epub 2008 Jul 20.
Abstract
This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.
摘要
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