Kim Kwangho, Miller Nicole R, Sulikowski Gary A, Lindsley Craig W
Department of Chemistry and Pharmacology, Institute of Chemical Biology, Vanderbilt University, 802 Robinson Research Building, Nashville, TN 37235-1822, USA.
Bioorg Med Chem Lett. 2008 Aug 15;18(16):4467-9. doi: 10.1016/j.bmcl.2008.07.065. Epub 2008 Jul 20.
This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.
本信函描述了一种新的多克级合成方案，用于制备D(2/3)正电子发射断层显像（PET）剂[(18)F]法螺必利的经典对甲苯磺酸酯标记前体。在我们的研究过程中，我们还发现了两种新型标记前体，即此前未描述的法螺必利的甲磺酸酯和氯代类似物。
