Daskalakis George, Anastasakis Eleftherios, Papantoniou Nikolaos, Mesogitis Spyros, Antsaklis Aris
First Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, Athens University, Athens, Greece.
Fertil Steril. 2009 Jun;91(6):2572-7. doi: 10.1016/j.fertnstert.2008.03.080.
To compare the outcome of amniocentesis in twins conceived with assisted reproduction technology (ART) versus spontaneously conceived twins.
Retrospective analysis of case records between 1993 and 2006.
University-affiliated tertiary center for fetal medicine.
PATIENT(S): 167 ART twin pregnancies and 275 spontaneous twin pregnancies.
INTERVENTION(S): Genetic amniocentesis.
MAIN OUTCOME MEASURE(S): Comparison of pregnancy loss rate and perinatal outcome between the ART and spontaneous twin-pregnancy groups.
RESULT(S): The fetal loss rate was similar between the two groups (4.2% vs. 4.0% in the ART twins and spontaneous twins, respectively), although the interval between amniocentesis to miscarriage was statistically significantly shorter in the ART twins than the spontaneous twins (6.2 and 20.1 days, respectively). In all cases, fetal loss refers to the loss of the entire pregnancy. The preterm delivery rate before 37 weeks was statistically significantly higher in the ART group (64.1%) compared with controls (49.5%).
CONCLUSION(S): Amniocentesis in ART twins carries a fetal loss rate similar to spontaneous twins. However, ART twins have a statistically significantly increased risk of preterm delivery especially before 32 weeks' gestation.
比较辅助生殖技术（ART）受孕的双胎妊娠与自然受孕双胎妊娠行羊膜腔穿刺术的结果。
对1993年至2006年病例记录进行回顾性分析。
大学附属三级胎儿医学中心。
167例ART双胎妊娠和275例自然双胎妊娠。
基因羊膜腔穿刺术。
比较ART双胎妊娠组和自然双胎妊娠组的妊娠丢失率和围产期结局。
两组胎儿丢失率相似（ART双胎和自然双胎分别为4.2%和4.0%），尽管ART双胎妊娠羊膜腔穿刺术后至流产的间隔时间在统计学上显著短于自然双胎妊娠（分别为6.2天和20.1天）。在所有病例中，胎儿丢失指整个妊娠丢失。ART组37周前的早产率在统计学上显著高于对照组（64.1%对49.5%）。
ART双胎妊娠行羊膜腔穿刺术的胎儿丢失率与自然双胎妊娠相似。然而，ART双胎妊娠早产风险在统计学上显著增加，尤其是在妊娠32周前。
