Hansen Michèle, Colvin Lyn, Petterson Beverly, Kurinczuk Jennifer J, de Klerk Nicholas, Bower Carol
Centre for Child Health Research, Telethon Institute for Child Health Research, The University of Western Australia, West Perth, WA 6872, Australia.
Hum Reprod. 2009 Sep;24(9):2321-31. doi: 10.1093/humrep/dep173. Epub 2009 May 20.
Compared with spontaneously conceived (SC) singletons, adverse perinatal outcome, neonatal intensive care unit (NICU) admission and hospital admission in infancy are more common in those born following Assisted Reproductive Technology (ART). Similar comparisons for twins have shown conflicting results.
We investigated perinatal outcome and hospital admission during the first 3 years of life for all twin children born in Western Australia between 1994 and 2000 [700 ART, 4097 SC].
ART twins had a greater risk of adverse perinatal outcome including preterm birth, low birthweight and death compared with SC twins of unlike-sex. In their first year of life, ART twins had a longer birth admission; were 60% more likely to be admitted to a NICU; and had a higher risk of hospital admission. The increased risk of hospital admission continued in the second and third year but was not statistically significant in the third year.
Couples undertaking ART should be aware that in addition to the known increased perinatal risks associated with a twin birth, ART twins are more likely than SC twins to be admitted to a NICU and hospitalized in the first 3 years of life.
与自然受孕的单胎相比，辅助生殖技术（ART）出生的婴儿围产期不良结局、新生儿重症监护病房（NICU）收治及婴儿期住院更为常见。对双胞胎进行的类似比较结果相互矛盾。
我们调查了1994年至2000年间在西澳大利亚出生的所有双胞胎儿童在生命最初3年的围产期结局和住院情况[700例ART双胞胎，4097例自然受孕双胞胎]。
与不同性别的自然受孕双胞胎相比，ART双胞胎出现包括早产、低出生体重和死亡在内的围产期不良结局的风险更高。在出生后的第一年，ART双胞胎住院时间更长；入住NICU的可能性高出60%；住院风险更高。住院风险增加在第二年和第三年持续存在，但在第三年无统计学意义。
接受ART的夫妇应意识到，除了已知的双胞胎出生相关围产期风险增加外，ART双胞胎在生命的前3年比自然受孕双胞胎更有可能入住NICU并住院。
