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重度抑郁症中的下丘脑-垂体-肾上腺轴：经典理论与新进展

The HPA axis in major depression: classical theories and new developments.

作者信息

Pariante Carmine M, Lightman Stafford L

机构信息

Institute of Psychiatry, King's College London, Division of Psychological Medicine and Psychiatry, Centre for the Cellular Basis of Behaviour, London, UK.

出版信息

Trends Neurosci. 2008 Sep;31(9):464-8. doi: 10.1016/j.tins.2008.06.006. Epub 2008 Jul 31.

DOI:10.1016/j.tins.2008.06.006
PMID:18675469
Abstract

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

摘要

过去40年的研究表明，下丘脑-垂体-肾上腺轴功能亢进是重度抑郁症精神病学中最一致的生物学发现之一，但这种异常背后的机制仍不清楚。

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