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促性腺激素释放激素激动剂与拮抗剂在控制性卵巢刺激中的应用：它们在先验预后不良患者中的作用

GnRH agonist versus GnRH antagonist in controlled ovarian hyperstimulation: their role in patients with an unfavorable prognosis a priori.

作者信息

Orvieto Raoul, Homburg Roy, Meltcer Simion, Rabinson Jacob, Anteby Eyal Y, Scharf Shimon

机构信息

Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1378-80. doi: 10.1016/j.fertnstert.2008.04.028. Epub 2008 Aug 3.

DOI:10.1016/j.fertnstert.2008.04.028
PMID:18675972
Abstract

In an attempt to examine the influence of the type of GnRH analogue used during controlled ovarian hyperstimulation on IVF outcome in patients with an unfavorable outcome a priori, we studied 728 consecutive cycles in patients with repeated IVF failure. In patients with repeated failure, the GnRH agonist group showed significantly higher clinical pregnancy rate compared with the GnRH antagonist group (20.8% vs 14.5%).

摘要

为了研究在控制性卵巢刺激过程中使用的促性腺激素释放激素（GnRH）类似物类型对预先存在不良结局患者体外受精（IVF）结果的影响，我们对728例连续进行IVF但失败的患者周期进行了研究。在反复失败的患者中，GnRH激动剂组的临床妊娠率显著高于GnRH拮抗剂组（20.8%对14.5%）。

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GnRH agonist versus GnRH antagonist in controlled ovarian hyperstimulation: their role in patients with an unfavorable prognosis a priori.促性腺激素释放激素激动剂与拮抗剂在控制性卵巢刺激中的应用：它们在先验预后不良患者中的作用
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引用本文的文献

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[Factors related to clinical pregnancy outcomes of in vitro fertilization-embryo transfer in women with secondary infertility].[继发性不孕女性体外受精-胚胎移植临床妊娠结局的相关因素]
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 May;44(3):237-46. doi: 10.3785/j.issn.1008-9292.2015.05.01.
2
Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing.使用下一代测序进行胚胎植入前遗传学诊断和筛查的临床结果。
Gigascience. 2014 Dec 4;3(1):30. doi: 10.1186/2047-217X-3-30. eCollection 2014.
3
Comparison of the GnRH agonist and antagonist protocol on the same patients in assisted reproduction during controlled ovarian stimulation cycles.
在控制性卵巢刺激周期的辅助生殖过程中，对同一批患者使用促性腺激素释放激素激动剂方案和拮抗剂方案的比较。
Int J Clin Exp Pathol. 2013 Aug 15;6(9):1903-10. eCollection 2013.