Yasuno Yoshiaki, Miura Masahiro, Kawana Keisuke, Makita Shuichi, Sato Masaki, Okamoto Fumiki, Yamanari Masahiro, Iwasaki Takuya, Yatagai Toyohiko, Oshika Tetsuro
Computational Optics Group, Institute of Applied Physics, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan.
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):405-13. doi: 10.1167/iovs.08-2272. Epub 2008 Aug 1.
To evaluate the clinical significance of the newly developed long-wavelength probe optical coherence tomography (LP-OCT) for the diagnosis of exudative macular diseases.
Fourteen eyes of 13 participants were prospectively enrolled in the study. There were seven type I and five type II choroidal neovascularization (CNV) cases associated with age-related macular degeneration and idiopathic neovascularization and one case of polypoidal choroidal vasculopathy (PCV). A custom-built LP-OCT based on swept-source OCT (SS-OCT) technology was used. This new OCT uses a probe beam with a wavelength of 1060 nm that provides deeper penetration into the choroid and higher image contrast to the structures beneath the retinal pigment epithelium (RPE) and pathologic tissues than does conventional OCT. The depth resolution is 10.4 microm in tissue and the measurement speed is 28,000 depth scans/s. All the eyes were also examined by standard short wavelength probe OCT (SP-OCT). The image contrasts of the LP- and SP-OCT were qualitatively evaluated and analyzed by Wilcoxon's paired signed rank test and Spearman's rank correlation test.
In 10 of 14 eyes, high-contrast visualization of the diseases beneath the RPE, CNV, or fibrin was attained. These diseases were almost invisible in the SP-OCT images. The LP-OCT of the remaining eyes also revealed significant improvement in the image contrasts beneath the RPE and CNV. Qualitative evaluation of the image contrasts and subsequent statistical test indicated statistically significant improvement in the image penetration to the choroid of LP-OCT to that of SP-OCT.
LP-OCT provided significant improvement in the image contrast of exudative macular diseases.
评估新开发的长波长探头光学相干断层扫描（LP-OCT）在渗出性黄斑疾病诊断中的临床意义。
前瞻性纳入13名参与者的14只眼进行研究。其中有7例I型和5例II型脉络膜新生血管（CNV）病例，与年龄相关性黄斑变性和特发性新生血管形成相关，还有1例息肉样脉络膜血管病变（PCV）。使用基于扫频源光学相干断层扫描（SS-OCT）技术定制的LP-OCT。这种新型光学相干断层扫描使用波长为1060 nm的探测光束，与传统光学相干断层扫描相比，它能更深入地穿透脉络膜，并能提供更高的视网膜色素上皮（RPE）下方结构和病理组织的图像对比度。组织中的深度分辨率为10.4微米，测量速度为28,000次深度扫描/秒。所有眼睛还接受了标准短波长探头光学相干断层扫描（SP-OCT）检查。通过Wilcoxon配对符号秩检验和Spearman秩相关检验对LP-OCT和SP-OCT的图像对比度进行定性评估和分析。
14只眼中的10只，实现了RPE、CNV或纤维蛋白下方疾病的高对比度可视化。这些疾病在SP-OCT图像中几乎不可见。其余眼睛的LP-OCT也显示RPE和CNV下方的图像对比度有显著改善。对图像对比度的定性评估及后续统计检验表明，LP-OCT对脉络膜的图像穿透性相对于SP-OCT有统计学上的显著改善。
LP-OCT显著改善了渗出性黄斑疾病的图像对比度。
