Akkaya Serkan, Ulusoy Dondu Melek, Dogan Hatice, Arslan Mahmut Erkam
Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
Department of Ophthalmology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Beyoglu Eye J. 2021 Sep 17;6(3):161-165. doi: 10.14744/bej.2021.09821. eCollection 2021.
This study was a comparison of the thickness of the choroid in pediatric patients with attention-deficit hyperactivity disorder (ADHD) and healthy pediatric controls.
This study was comparative, cross-sectional, and observational in design. The healthy controls were age- and sex-matched with the members of the ADHD group and had no history of psychosis. Choroidal thickness was determined using spectral-domain optical coherence tomography.
A total of 138 patients were enrolled with a male:female ratio of 54 (69.2%): 24 (30.8%) in the ADHD group and 41 (68.3%): 19 (31.7%) in the control group (p=0.910). The ADHD patients had a mean age of 9.4±1.9 years (range: 6-12 years) and the controls had a mean age of 9.9±2.2 years (range: 6-12 years) (p=0.213). The ADHD group (n=78 eyes tested) had a significantly higher mean choroidal thickness at 1.5 mm (temporal-to-fovea, TTF) measurement than the controls (n=60 eyes tested) (281.12±46.63 μm vs. 264.40±48.61 μm, p=0.042). There were no significant differences in any of the other choroidal thickness measurements (p>0.05).
The choroidal thickness measurement (TTF) at 1.5 mm was significantly greater in the ADHD patients. These findings suggest that choroidal thickness alterations may have a potential role in the underlying etiology of ADHD.
本研究旨在比较患有注意力缺陷多动障碍（ADHD）的儿科患者与健康儿科对照者的脉络膜厚度。
本研究为比较性、横断面观察性研究。健康对照者在年龄和性别上与ADHD组成员匹配，且无精神病病史。使用光谱域光学相干断层扫描测定脉络膜厚度。
共纳入138例患者，ADHD组男女比例为54例（69.2%）：24例（30.8%），对照组为41例（68.3%）：19例（31.7%）（p = 0.910）。ADHD患者的平均年龄为9.4±1.9岁（范围：6 - 12岁），对照组的平均年龄为9.9±2.2岁（范围：6 - 12岁）（p = 0.213）。ADHD组（78只眼接受检测）在1.5毫米处（颞侧至黄斑中心凹，TTF）的平均脉络膜厚度显著高于对照组（60只眼接受检测）（281.12±46.63微米 vs. 264.40±48.61微米，p = 0.042）。在其他任何脉络膜厚度测量中均无显著差异（p>0.05）。
ADHD患者在1.5毫米处的脉络膜厚度测量值（TTF）显著更大。这些发现表明脉络膜厚度改变可能在ADHD的潜在病因中起作用。
