与甲氧苄啶相关的氨噻二嗪二氧化物的合成及生物学筛选
Synthesis and biological screening of aminothiadiazine dioxides related to trimethoprim.
作者信息
Alkorta I, Goya P, Nombela C, Medina R, Pérez Martín C
机构信息
Instituto de Quimica Médica, Madrid, Spain.
出版信息
Arzneimittelforschung. 1991 Mar;41(3):264-6.
PMID:1867665
Abstract
New derivatives of 3-amino-1,2,6-thiadiazine 1,1-dioxide have been synthesized and their antibacterial, antifungal and DHFR inhibitory activities evaluated. Their chemical structures have been established by means of analytical and NMR spectroscopic data. Among the compounds studied, the 4,4-dibromo derivative 11 showed fungistatic activity against C. albicans.
摘要
合成了3-氨基-1,2,6-噻二嗪1,1-二氧化物的新衍生物，并评估了它们的抗菌、抗真菌和二氢叶酸还原酶抑制活性。通过分析和核磁共振光谱数据确定了它们的化学结构。在所研究的化合物中，4,4-二溴衍生物11对白色念珠菌显示出抑菌活性。
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