3-芳基氨基甲基-7H-6-(6-取代-3-香豆素基)-S-三唑并-[3,4-b][1,3,4]噻二嗪的合成及生物活性研究

Synthesis and biological activity studies of 3-arylaminomethyl-7H-6-(6 substituted-3-coumarino)-S-triazolo-[3,4-b][1,3,4]thiadiazines.

作者信息

Kalluraya B, Vishwanath P

机构信息

Department of Studies in Chemistry, Mangalore University, Mangalagangothri, India.

出版信息

Boll Chim Farm. 1998 May;137(5):169-72.

Abstract

Several new 3-arylaminomethyl-7H-6-(6-substituted-3-coumarino)-s-triazol o-[3,4-b] [1,3,4]thiadiazines were synthesized by condensing 3-arylaminomethyl-4-amino-5-mercapto-1,2,4-triazoles with 3-bromoacetyl-6-substituted coumarins in dioxan medium. The structures of newly synthesized compounds were established on the basis of analytical, NMR and mass spectral data. Some selected compounds from this series were subjected to antibacterial studies.

摘要

通过在二氧六环介质中将3-芳基氨基甲基-4-氨基-5-巯基-1,2,4-三唑与3-溴乙酰基-6-取代香豆素缩合，合成了几种新的3-芳基氨基甲基-7H-6-(6-取代-3-香豆素基)-s-三唑并[3,4-b][1,3,4]噻二嗪。根据分析、核磁共振和质谱数据确定了新合成化合物的结构。对该系列中的一些选定化合物进行了抗菌研究。

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