Biernat S, Kulig A, Lepert R, Orlowski T
Pol Med Sci Hist Bull (1973). 1976 Jan-Mar;15(1):87-97.
Dog kidneys were studied morphologically and histochemically after hemodilution to a 10--20% hematocrict value and transfusion of whole blood under conditions of extracorporeal circulation ensuring constant (linear) flow. Marked interstitial edema in the dog kidneys after hemodilution was the most pronounced alteration, attributed to disorders in the capillary circulation depending upon the apparatus employed. This conclusion was supported by similar changes in animals subjected to various degrees of hemodilution. Widening of the glomerular space and compression of renal tubules were the direct consequences of interstitial edema. Histochemical reactions revealed damage of the cell membranes. Swelling of the ergastoplasm and lysosomes was interpreted as secondary to disorders in circulation of tissue fluid. The least pronounced changes concerned the mitochondria. After extracorporeal circulation with whole blood, thrombi and fat emboli were observed in the blood vessels of the renal glomeruli, attributable to damage of blood in the extracorporeal circulation apparatus.
在体外循环确保恒定（线性）血流的条件下，将狗的血液稀释至血细胞比容值为10%-20%并输注全血后，对狗肾进行了形态学和组织化学研究。血液稀释后狗肾中明显的间质水肿是最显著的改变，这归因于所使用设备导致的毛细血管循环紊乱。不同程度血液稀释的动物出现的类似变化支持了这一结论。肾小球间隙增宽和肾小管受压是间质水肿的直接后果。组织化学反应显示细胞膜受损。内质网和溶酶体肿胀被解释为组织液循环紊乱的继发性结果。最不明显的变化涉及线粒体。全血体外循环后，在肾小球血管中观察到血栓和脂肪栓子，这归因于体外循环设备中血液的损伤。
