[Disruption of the morphofunctional state of hepatocytes and microcirculation in the liver during prolonged artificial circulation in dogs].

Qualitative and quantitative analysis was made of morpho-functional and enzymatic changes in the dog liver during long-term extracorporeal circulation. Pronounced necrotic alterations of hepatocytes and microcirculatory disorders were detected by the end of 3-hour extracorporeal circulation. The data obtained indicate the need for correction of circulation in the terminal parts of the vascular bed.