Rozental Tamara D, Zurakowski David, Blazar Philip E
Harvard Medical School, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 10, Boston, MA 02215, USA.
J Bone Joint Surg Am. 2008 Aug;90(8):1665-72. doi: 10.2106/JBJS.G.00693.
Corticosteroid injections are commonly used in the treatment of flexor tenosynovitis in adults. The present study was performed in an attempt to identify prognostic indicators of symptom recurrence one year after corticosteroid injection for the treatment of trigger digits.
One hundred and thirty consecutive patients with trigger digits treated with corticosteroid injection were prospectively enrolled. Exclusion criteria were prior treatment and inflammatory arthritis. Demographic data and information on existing comorbidities were identified with a questionnaire. Patients were contacted at one year after treatment to determine symptom recurrence. Kaplan-Meier analysis and the Cox regression model were used to estimate recurrence rates and identify predictors.
One hundred and twenty-four trigger digits in 119 patients (average age, 62.3 years) were included. The most commonly involved digits were the thumb (35% of the digits), ring finger (31%), and long finger (23%). Seventy digits (56%) had a recurrence of symptoms at a median of 5.6 months (range, 0.5 to 13.1 months) after the injection. Twenty-two digits (18%) underwent surgical release at a median of 7.4 months after the injection. According to the Kaplan-Meier analysis, the estimated rate of freedom from symptom recurrence was 70% (95% confidence interval, 63% to 77%) at six months and 45% (95% confidence interval, 36% to 54%) at twelve months and the estimated rate of freedom from surgical release was 95% (95% confidence interval, 92% to 98%) at six months and 83% (95% confidence interval, 77% to 89%) at twelve months. Insulin-dependent diabetes mellitus was identified as a strong predictor of symptom recurrence (p < 0.01). Younger age (p < 0.01), involvement of other digits prior to presentation (p < 0.01), and a history of other tendinopathies of the upper extremity (p = 0.02) were all independent predictors of a surgical release. The duration and severity of symptoms were not predictive of poor outcomes following injections.
At one year following injection, 56% of the digits had a recurrence of symptoms. Younger age, insulin-dependent diabetes mellitus, involvement of multiple digits, and a history of other tendinopathies of the upper extremity were associated with a higher rate of treatment failure. Symptoms often recurred several months after the injection.
皮质类固醇注射常用于治疗成人屈指肌腱狭窄性腱鞘炎。本研究旨在确定皮质类固醇注射治疗扳机指一年后症状复发的预后指标。
前瞻性纳入130例连续接受皮质类固醇注射治疗的扳机指患者。排除标准为既往治疗史和炎性关节炎。通过问卷调查确定人口统计学数据和现有合并症信息。在治疗一年后联系患者以确定症状复发情况。采用Kaplan-Meier分析和Cox回归模型来估计复发率并确定预测因素。
纳入119例患者的124个扳机指(平均年龄62.3岁)。最常受累的手指为拇指(占手指的35%)、环指(31%)和中指(23%)。70个手指(56%)在注射后中位时间5.6个月(范围0.5至13.1个月)出现症状复发。22个手指(18%)在注射后中位时间7.4个月接受了手术松解。根据Kaplan-Meier分析,症状复发的估计无复发率在6个月时为70%(95%置信区间,63%至77%),在12个月时为45%(95%置信区间,36%至54%);手术松解的估计无复发率在6个月时为95%(95%置信区间,92%至98%),在12个月时为83%(95%置信区间,77%至89%)。胰岛素依赖型糖尿病被确定为症状复发的强预测因素(p<0.01)。年龄较小(p<0.01)、就诊前其他手指受累(p<0.01)以及上肢其他肌腱病病史(p = 0.02)均为手术松解的独立预测因素。症状的持续时间和严重程度不能预测注射后的不良结局。
注射后一年,56%的手指出现症状复发。年龄较小、胰岛素依赖型糖尿病、多个手指受累以及上肢其他肌腱病病史与较高的治疗失败率相关。症状常在注射后数月复发。