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德·奎尔万腱鞘炎:单次皮质类固醇注射后的生存率及复发预后指标

De Quervain tendinopathy: survivorship and prognostic indicators of recurrence following a single corticosteroid injection.

作者信息

Earp Brandon E, Han Carin H, Floyd W Emerson, Rozental Tamara D, Blazar Philip E

机构信息

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA.

出版信息

J Hand Surg Am. 2015 Jun;40(6):1161-5. doi: 10.1016/j.jhsa.2014.12.027. Epub 2015 Apr 30.

Abstract

PURPOSE

To determine short- and long-term success rates of a single corticosteroid injection for de Quervain tendinopathy while identifying prognostic indicators for symptom recurrence and repeat intervention.

METHODS

Fifty consecutive patients with de Quervain tendinopathy treated with corticosteroid injections (lidocaine plus triamcinolone acetonide or dexamethasone) were prospectively enrolled. Patients with inflammatory arthritis, carpometacarpal osteoarthritis, or a previous distal radius fracture affecting the symptomatic wrist were excluded. Demographic data and information on existing comorbidities were recorded. Patients were seen in clinic at 6 weeks after injection and contacted at 3, 6, 9, and 12 months following injection to determine symptom recurrence and further intervention. Medical records were also reviewed for this purpose. Kaplan-Meier survival analysis and Cox regression modeling were used to estimate recurrence rates and identify predictors of symptom recurrence and repeat intervention.

RESULTS

Fifty wrists in 50 patients (average age, 49 y) were included. One patient was lost to follow-up. Eighty-two percent of patients had resolved symptoms 6 weeks after a steroid injection. Twenty-four patients had a recurrence of symptoms at a median of 84 days after the injection. Eleven patients underwent additional intervention (7 surgical releases and 4 repeat injections) at a median of 129 days (range, 42-365) after the injection. Estimated freedom from symptom recurrence was 52% at 6 and 12 months. Estimated freedom from repeat intervention was 81% at 6 months and 77% at 12 months. Two of 3 patients with a history of trigger finger required subsequent de Quervain surgery.

CONCLUSIONS

We demonstrated that a single cortisone injection was effective in alleviating symptoms of de Quervain tendinopathy in 82% of patients and that over half remained symptom-free for at least 12 months. All patients with recurring symptoms developed them within the first 6 months.

TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV.

摘要

目的

确定单次皮质类固醇注射治疗桡骨茎突狭窄性腱鞘炎的短期和长期成功率,同时确定症状复发和再次干预的预后指标。

方法

前瞻性纳入50例连续接受皮质类固醇注射(利多卡因加曲安奈德或地塞米松)治疗的桡骨茎突狭窄性腱鞘炎患者。排除患有炎性关节炎、腕掌关节骨关节炎或既往有影响患侧手腕的桡骨远端骨折的患者。记录人口统计学数据和现有合并症信息。患者在注射后6周在门诊就诊,并在注射后3、6、9和12个月进行随访,以确定症状复发情况和进一步干预措施。为此还查阅了病历。采用Kaplan-Meier生存分析和Cox回归模型来估计复发率,并确定症状复发和再次干预的预测因素。

结果

纳入50例患者的50侧手腕(平均年龄49岁)。1例患者失访。82%的患者在类固醇注射后6周症状缓解。24例患者在注射后中位84天出现症状复发。11例患者在注射后中位129天(范围42 - 365天)接受了额外干预(7例手术松解和4例重复注射)。6个月和12个月时估计无症状复发率分别为52%。6个月时估计无需再次干预率为81%,12个月时为77%。3例有扳机指病史的患者中有2例随后需要进行桡骨茎突狭窄性腱鞘炎手术。

结论

我们证明单次可的松注射可有效缓解82%患者的桡骨茎突狭窄性腱鞘炎症状,且超过半数患者至少12个月无症状。所有复发症状的患者均在最初6个月内出现症状。

研究类型/证据水平:预后性研究IV级

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