Sun Hong-zan, Fan Guo-guang, Wang Gui-ling, Guo Qi-yong
Department of Radiology, Shengjing Hospital of China Medical University, Shengyang, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2008 Aug 18;40(4):446-9.
Seizures may be the first or sometimes the only manifestation of patients with glioma in clinics. The aim of operation is to eliminate epilepsy far beyond mere resection of tumor mass. The underlying mechanisms of glioma-associated epileptogenesis are poorly understood. Recently the theory of amino-acid like neurotransmitters in chemical synapse is gradually accepted. However, the molecular mechanisms remain to be further investigated on how glutamate release is regulated and how synaptic homeostasis in peripheral neurons is kept or disturbed. So detailed studies are needed to clarify specific molecular target and provide proper evidence for optimal antiepileptic drugs in glioma-associated epileptogenesis.
癫痫发作可能是胶质瘤患者临床上最早出现的症状，有时甚至是唯一症状。手术的目的不仅仅是切除肿瘤块，更要消除癫痫。目前对胶质瘤相关癫痫发生的潜在机制了解甚少。最近，化学突触中类似氨基酸神经递质的理论逐渐被接受。然而，关于谷氨酸释放如何被调节以及外周神经元的突触稳态如何维持或被破坏的分子机制仍有待进一步研究。因此，需要进行详细研究以阐明具体分子靶点，并为胶质瘤相关癫痫发生中最佳抗癫痫药物提供适当依据。
