胶质瘤中氨基酸神经递质水平及其与癫痫发病率的关系。

Amino acid neurotransmitter levels in gliomas and their relationship to the incidence of epilepsy.

作者信息

Bateman D E, Hardy J A, McDermott J R, Parker D S, Edwardson J A

机构信息

Wessex Neurological Centre, Southampton General Hospital, Shirley, UK.

出版信息

Neurol Res. 1988 Jun;10(2):112-4. doi: 10.1080/01616412.1988.11739825.

DOI:10.1080/01616412.1988.11739825

PMID:2902524

Abstract

The cause of epilepsy due to gliomas is not known. Explanations that is due to mass effect, infiltration and site of the tumour appear insufficient. We have investigated the possibility that epilepsy due to gliomas is caused by interference with normal GABA and glutamate uptake and metabolism in the surrounding cortex. Analysis of human glioma biopsy specimens for the amino acid neurotransmitters and glutamine has shown that gliomas associated with epilepsy have a higher concentration of glutamine. This may be of importance since an elevated concentration of glutamine has been shown to be associated with the onset and severity of cobalt-induced epilepsy.

摘要

胶质瘤所致癫痫的病因尚不清楚。认为是由肿块效应、浸润及肿瘤部位引起的解释似乎并不充分。我们研究了胶质瘤所致癫痫是由周围皮质中正常γ-氨基丁酸（GABA）和谷氨酸摄取及代谢受到干扰所引起的可能性。对人类胶质瘤活检标本进行氨基酸神经递质和谷氨酰胺分析表明，与癫痫相关的胶质瘤谷氨酰胺浓度较高。这可能具有重要意义，因为已表明谷氨酰胺浓度升高与钴诱导的癫痫发作及严重程度相关。