Bateman D E, Hardy J A, McDermott J R, Parker D S, Edwardson J A
Wessex Neurological Centre, Southampton General Hospital, Shirley, UK.
Neurol Res. 1988 Jun;10(2):112-4. doi: 10.1080/01616412.1988.11739825.
The cause of epilepsy due to gliomas is not known. Explanations that is due to mass effect, infiltration and site of the tumour appear insufficient. We have investigated the possibility that epilepsy due to gliomas is caused by interference with normal GABA and glutamate uptake and metabolism in the surrounding cortex. Analysis of human glioma biopsy specimens for the amino acid neurotransmitters and glutamine has shown that gliomas associated with epilepsy have a higher concentration of glutamine. This may be of importance since an elevated concentration of glutamine has been shown to be associated with the onset and severity of cobalt-induced epilepsy.
胶质瘤所致癫痫的病因尚不清楚。认为是由肿块效应、浸润及肿瘤部位引起的解释似乎并不充分。我们研究了胶质瘤所致癫痫是由周围皮质中正常γ-氨基丁酸（GABA）和谷氨酸摄取及代谢受到干扰所引起的可能性。对人类胶质瘤活检标本进行氨基酸神经递质和谷氨酰胺分析表明，与癫痫相关的胶质瘤谷氨酰胺浓度较高。这可能具有重要意义，因为已表明谷氨酰胺浓度升高与钴诱导的癫痫发作及严重程度相关。
