Zhu Haiyan, Zhao Dandan, Han Xiaoping, Sun Jingfen, Da Wanming, Yu Li, Gao Chunji
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Int J Hematol. 2008 Oct;88(3):321-323. doi: 10.1007/s12185-008-0145-9. Epub 2008 Aug 2.
A new allele of the human leukocyte antigen C (HLA-C) locus was identified during routine HLA typing of a Chinese hematopoietic stem cell donor in Beijing, China. Sequence analysis of exons 2 and 3 of the HLA-C gene revealed the novel polymorphism. The closest matched allele was HLA-Cw0710. A comparison of the two alleles showed that HLA-Cw0743 carried a nucleotide substitution of C to A at codon 99 in exon 3, resulting in an amino acid substitution of serine to tyrosine with no obvious change in protein structure.
在中国北京对一名中国造血干细胞供者进行常规人类白细胞抗原C（HLA-C）基因分型时，发现了HLA-C基因座的一个新等位基因。对HLA-C基因第2和第3外显子的序列分析揭示了这种新的多态性。最匹配的等位基因是HLA-Cw0710。对这两个等位基因的比较显示，HLA-Cw0743在第3外显子的第99密码子处发生了C到A的核苷酸替换，导致氨基酸由丝氨酸替换为酪氨酸，而蛋白质结构无明显变化。
