Cheng L-H, Li Z, Jin S-Z, Zou H-Y
Immunogenetic Laboratory, Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong, China.
Tissue Antigens. 2008 Nov;72(5):495-7. doi: 10.1111/j.1399-0039.2008.01117.x. Epub 2008 Sep 5.
The novel human leukocyte antigen (HLA)-Cw0340 allele was identified by sequence-based typing in a Chinese individual. This allele shows that the sequences of exons 2-3 of HLA-Cw0340 are identical to those of HLA-Cw0302, except for a nucleotide substitution that changes CTC to ATC at codon 95, resulting in an amino acid change from Leu to lle in the protein; this allele also shows that the sequences of exons 2-3 of HLA-Cw0340 are identical to those of HLA-Cw030401 or HLA-Cw030403, except for a nucleotide substitution that changes TAC to TCC at codon 116, resulting in an amino acid change from Try to Ser in the protein.
通过基于序列的分型方法，在中国个体中鉴定出了新型人类白细胞抗原（HLA）-Cw0340等位基因。该等位基因显示，HLA-Cw0340外显子2-3的序列与HLA-Cw0302的序列相同，只是在第95密码子处有一个核苷酸替换，将CTC变为ATC，导致蛋白质中的氨基酸从Leu变为Ile；该等位基因还显示，HLA-Cw0340外显子2-3的序列与HLA-Cw030401或HLA-Cw030403的序列相同，只是在第116密码子处有一个核苷酸替换，将TAC变为TCC，导致蛋白质中的氨基酸从Try变为Ser。
