Steenbergen H L, Farabollini F, Heinsbroek R P, Van de Poll N E
Netherlands Institute for Brain Research, Amsterdam.
Behav Brain Res. 1991 May 15;43(2):159-65. doi: 10.1016/s0166-4328(05)80066-x.
The behavioral effects of exposure to inescapable shocks (IS) were studied in both the holeboard and the elevated plus-maze, 24 and 72 h after IS in male and female Wistar rats. The following effects were observed at the 24-h interval. In both sexes, head-dipping in the holeboard was reduced by IS, whereas general activity (ambulation and rearing) was reduced in males and not in females. Furthermore, the results of a correlation analysis indicate that previous exposure to IS disrupts the dissociation observed in control groups between exploratory activity directed at the holes (head-dipping) and general activity in the holeboard (ambulation and rearing). Effects of IS on plus-maze behavior could be observed in a clear suppression of rearing in males and not in females. IS did not affect time spent on the open arms. At the 72-h interval, IS affected head-dipping in the holeboard only in males and not in females. The present findings show that the effect of IS on specified behavioral elements is sex-dependent, with stronger and longer-lasting effects in males than in females.
在雄性和雌性Wistar大鼠遭受不可逃避电击（IS）后的24小时和72小时，分别在洞板实验和高架十字迷宫实验中研究了IS暴露的行为效应。在24小时间隔时观察到以下效应。在两性中，IS均使洞板实验中的探洞行为减少，而雄性的一般活动（行走和站立）减少，雌性则未减少。此外，相关分析结果表明，先前的IS暴露破坏了对照组中观察到的针对洞的探索活动（探洞）与洞板中的一般活动（行走和站立）之间的分离。IS对十字迷宫行为的影响表现为明显抑制雄性的站立行为，而雌性则未受影响。IS不影响在开放臂上花费的时间。在72小时间隔时，IS仅影响雄性洞板实验中的探洞行为，雌性则未受影响。目前的研究结果表明，IS对特定行为要素的影响具有性别依赖性，对雄性的影响比对雌性更强且持续时间更长。
