Asymmetric catalysis with metal complexes in nanoreactors.

Recently, the field of heterogeneous asymmetric catalysis, generally using chiral solid catalysts, has attracted much attention in the production of single enantiomers. Among versatile chiral solid catalysts, chiral metal complexes confined in nanoreactors often exhibit very unique enantioselectivity and catalytic activity compared to homogeneous catalysts. In this Focus Review, we summarize the recent advances in asymmetric reactions on chiral metal complexes confined in nanoreactors with an emphasis on the confinement effect and cooperative activation effect of the nanoreactor and new strategies for the preparation of chiral solid catalysts, such as the encapsulation of chiral metal complexes in the nanocages of mesoporous silica and incorporation of chiral ligands in the network of mesoporous organosilicas.