Rijpkema Sjoerd J, Toebes B Jelle, van Vlaenderen Jules, van Haren Liban, Wilson Daniela A
Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135 6525 AJ, Nijmegen, The Netherlands.
ACS Macro Lett. 2025 Jan 21;14(1):101-106. doi: 10.1021/acsmacrolett.4c00758. Epub 2025 Jan 6.
Lactide, possessing two stereocenters and thus three distinct configurations (DD, DL, and LL), serves as a captivating building block for polymers and self-assembly. Notably, polylactide (PLA) exhibits stereocomplexation, displaying heightened interactions between different configurations compared with interactions within the same configuration. This characteristic renders PLA an intriguing subject for investigating self-assembly behavior. In this study, 22 PEG--PLA polymers were synthesized and self-assembled, with analysis conducted through NMR and cryo-TEM techniques. A range of morphologies, including vesicles, diamond-shaped lamellae, and branched networks, were achieved by manipulating the tacticities. Enhanced comprehension of self-assembly interactions holds promise for advancing molecular recognition, self-replication, and asymmetric catalysis.
丙交酯具有两个立体中心，因而有三种不同构型（DD、DL和LL），是聚合物和自组装极具吸引力的构建单元。值得注意的是，聚丙交酯（PLA）表现出立体复合作用，与相同构型内的相互作用相比，不同构型之间的相互作用增强。这一特性使PLA成为研究自组装行为的一个有趣课题。在本研究中，合成并自组装了22种聚乙二醇-聚丙交酯（PEG-PLA）聚合物，并通过核磁共振（NMR）和冷冻透射电子显微镜（cryo-TEM）技术进行分析。通过控制立构规整度实现了一系列形态，包括囊泡、菱形片层和分支网络。对自组装相互作用的深入理解有望推动分子识别、自我复制和不对称催化的发展。
