Georgescu Simona Roxana, Tampa Mircea, Mitran Madalina Irina, Mitran Cristina Iulia, Sarbu Maria Isabela, Nicolae Ilinca, Matei Clara, Caruntu Constantin, Neagu Monica, Popa Mircea Ioan
Department of Dermatology, 'Victor Babes' Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.
Department of Dermatology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Exp Ther Med. 2019 Feb;17(2):1045-1051. doi: 10.3892/etm.2018.6987. Epub 2018 Nov 16.
Lichen planus (LP) is an immune-mediated inflammatory disease that particularly affects the skin and mucous membranes. Its etiology remains elusive, however some trigger factors, including viral or bacterial antigens, drugs and metals, have been postulated. There is a higher prevalence of hepatitis C virus (HCV) infection among patients with LP, with some geographical variations. HCV is an enveloped RNA virus that belongs to the Flaviviridae family and in most instances causes chronic liver infections. It has been hypothesized that HCV may contribute to LP development, but the link between the two disorders is not fully understood. It is still debatable whether HCV leads to the occurrence of LP lesions directly by replication inside the infected cells or indirectly by activating immunological pathways. Molecular studies have revealed HCV RNA in specimens collected from patients with LP. The autoimmune theory was also suggested given that several studies have revealed viral replication and immune response activation associated with autoantibody synthesis. The aim of this review is to summarize the main potential mechanisms involved in the association between LP and HCV infection. Understanding the link between the two disorders may shed some light on the pathogenesis of LP, which is a challenging issue.
扁平苔藓（LP）是一种免疫介导的炎症性疾病，特别影响皮肤和黏膜。其病因尚不清楚，不过已推测出一些触发因素，包括病毒或细菌抗原、药物和金属。LP患者中丙型肝炎病毒（HCV）感染的患病率较高，且存在一些地理差异。HCV是一种包膜RNA病毒，属于黄病毒科，在大多数情况下会导致慢性肝脏感染。据推测，HCV可能促成LP的发展，但这两种疾病之间的联系尚未完全明确。HCV是直接通过在受感染细胞内复制还是间接通过激活免疫途径导致LP皮损的发生，仍存在争议。分子研究已在从LP患者采集的标本中发现了HCV RNA。鉴于多项研究揭示了与自身抗体合成相关的病毒复制和免疫反应激活，自身免疫理论也被提出。本综述的目的是总结LP与HCV感染之间关联的主要潜在机制。了解这两种疾病之间的联系可能有助于阐明LP的发病机制，这是一个具有挑战性的问题。
