Wright Ian M R, Owers Marilyn, Wagner Mary
Kaleidoscope Neonatal Intensive Care Unit, John Hunter Children's Hospital, New South Wales, Australia.
Pediatr Crit Care Med. 2008 Sep;9(5):498-501. doi: 10.1097/PCC.0b013e318172d48d.
: An umbilical arterial catheter is often used to monitor blood pressure and take frequent blood samples in the very low birth weight newborn infant requiring neonatal intensive care. Incorrect placement of the umbilical arterial catheter increases catheter complications, and adjustment of catheter position after radiograph increases infant handling and infection risk. Current methods overestimate insertion length in very low birth weight babies. We suggest a new formula for calculating insertion length that is more appropriate for today's neonatal intensive care population. The Umbilical Arterial Catheter Calculation Study, Australian Perinatal Trials Register PT0398, was set up to investigate this technical change. Our hypothesis was that the new formula would improve the siting of umbilical arterial catheters in very low birth weight infants.
: Randomized control trial.
: Tertiary referral neonatal intensive care unit.
: All infants <1500 g who were free from major cardiovascular malformations and who received an umbilical arterial catheter for clinical reasons were eligible for the study.
: Infants were randomized to current practice, using a nomogram derived from Dunn (control), or to the new formula: insertional length (cm) = (4 x birth weight [kg]) + 7. Primary outcome was correct catheter position (T6-10) on initial radiograph.
: Seventy-four randomized infants had catheters successfully inserted. There were no significant differences between the groups in birth weight, gestational age, or gender. There was a significant increase in correctly sited catheters (p = .003) with the new formula. Overinsertion of the umbilical arterial catheter was significantly less likely (p < .0001). Underinsertion was not significantly increased. Umbilical arterial catheter manipulation after radiograph was decreased from 50% to 5% (p = .007). There was no increase in adverse effects.
: The use of the new formula results in better overall placement and in significantly less overinsertion of umbilical artery catheters in very low birth weight infants.
脐动脉导管常用于监测极低出生体重新生儿的血压,并在需要新生儿重症监护时频繁采集血样。脐动脉导管放置不当会增加导管相关并发症,而在X线检查后调整导管位置会增加对婴儿的操作及感染风险。目前的方法高估了极低出生体重儿的导管插入长度。我们提出一种新的计算插入长度的公式,该公式更适用于当今的新生儿重症监护人群。脐动脉导管计算研究(澳大利亚围产期试验注册编号PT0398)旨在研究这一技术变革。我们的假设是,新公式将改善极低出生体重儿脐动脉导管的放置情况。
随机对照试验。
三级转诊新生儿重症监护病房。
所有体重<1500g、无重大心血管畸形且因临床原因接受脐动脉导管置入的婴儿均符合研究条件。
婴儿被随机分为两组,一组采用根据邓恩(Dunn)图表得出的现行方法(对照组),另一组采用新公式:插入长度(cm)=(4×出生体重[kg])+7。主要结局是初次X线检查时导管位置正确(T6 - 10)。
74例随机分组的婴儿成功插入了导管。两组在出生体重、胎龄或性别方面无显著差异。新公式组导管位置正确的比例显著增加(p = 0.003)。脐动脉导管过度插入的可能性显著降低(p < 0.0001)。未显著增加插入不足的情况。X线检查后脐动脉导管的操作从50%降至5%(p = 0.007)。不良反应未增加。
使用新公式可使极低出生体重儿脐动脉导管的总体放置情况更好,且过度插入的情况显著减少。