Brown Stacie A, Palmer Kelli L, Whiteley Marvin
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, Texas 78712, USA.
Nat Rev Microbiol. 2008 Sep;6(9):657-66. doi: 10.1038/nrmicro1955.
The ability of the human body to play host to bacterial pathogens has been studied for more than 200 years. Successful pathogenesis relies on the ability to acquire the nutrients that are necessary for growth and survival, yet relatively little is understood about the in vivo physiology and metabolism of most human pathogens. This Review discusses how in vivo carbon sources can affect disease and highlights the concept that carbon metabolic pathways provide viable targets for antibiotic development.
人体作为细菌病原体宿主的能力已被研究了200多年。成功的致病过程依赖于获取生长和生存所需营养物质的能力，然而，对于大多数人类病原体的体内生理学和代谢，我们了解得相对较少。本综述讨论了体内碳源如何影响疾病，并强调了碳代谢途径为抗生素开发提供可行靶点的概念。
