Xiang Yang, Chen Jin-hong, Cai Duan, Ma Bao-jin
Department of General Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Chin J Integr Med. 2008 Jun;14(2):142-4. doi: 10.1007/s11655-008-0142-0. Epub 2008 Aug 6.
To observe the effect of Lidan Granule (, LDG) on bile lithogenic tendency and biliary 33.5 kd vesicular protein (VP) and to explore its mechanism.
Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group, the sodium cholate treated group for positive control, and the untreated control group, 20 patients in each group. The 4 bile lithogenic trend indexes, including lithogenic index (LI), unconjugated bilirubin percent (UCB%), unconjugated bilirubin saturation index (BSI) and Z-value, were determined before and after treatment. The content of VP in bile was determined as well.
Before treatment, the LI, UCB%, BSI and Z-value in the LDG treated group were 1.298+/- 0.265, 34.72+/-2.96, 0.353+/-0.093 and 0.556+/-0.499, respectively, which was decreased after the 2-week treatment to 0.926+/-0.208, 8.93+/-1.19, 0.154+/-0.056 and 0.257+/-0.211, respectively (all P<0.05). Meantime, the content of VP was also lowered from 0.050+/-0.005 g/L to 0.032+/-0.005 g/L. However, no significant change in any of the above-mentioned indexes was found in the other two groups.
LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.
观察利胆颗粒（LDG）对胆汁成石倾向及胆汁33.5kd囊泡蛋白（VP）的影响，并探讨其作用机制。
将60例胆总管结石合并胆囊结石患者随机分为LDG治疗组、胆酸钠治疗组作为阳性对照组和未治疗对照组，每组20例。治疗前后分别测定4项胆汁成石趋势指标，包括成石指数（LI）、非结合胆红素百分比（UCB%）、非结合胆红素饱和指数（BSI）和Z值。同时测定胆汁中VP的含量。
治疗前，LDG治疗组的LI、UCB%、BSI和Z值分别为1.298±0.265、34.72±2.96、0.353±0.093和0.556±0.499，治疗2周后分别降至0.926±0.208、8.93±1.19、0.154±0.056和0.257±0.211（均P<0.05）。同时，VP含量也从0.050±0.005g/L降至0.032±0.005g/L。然而，其他两组上述指标均无明显变化。
LDG可有效抑制胆汁成石倾向，降低胆汁中33.5kd VP的含量。
