卵巢储备功能评估：现状
Ovarian reserve evaluation: state of the art.
作者信息
de Carvalho Bruno Ramalho, Rosa e Silva Ana Carolina Japur de Sá, Rosa e Silva Júlio César, dos Reis Rosana Maria, Ferriani Rui Alberto, Silva de Sá Marcos Felipe
机构信息
Sector of Human Reproduction, Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
出版信息
J Assist Reprod Genet. 2008 Jul;25(7):311-22. doi: 10.1007/s10815-008-9241-2. Epub 2008 Aug 5.
PURPOSE
Revise role of hormonal basal and dynamic tests, as well as ultrasonographic measures as ovarian reserve markers, in order to provide better counseling to subfertile couples.
METHODS
Review of publications on the topic, with an emphasis on recent well designed articles.
RESULTS
Currently available ovarian reserve tests do not provide sufficient evidence to be solely considered ideal, even for premature ovarian senescence patients who do not present subfertility complaints. However, these markers occupy important place in initial approach to treatment of subfertile couples, predicting unsatisfactory results that could be improved by differentiated induction schemes and reducing excessive psychological and financial burdens, and adverse effects.
CONCLUSIONS
In order to remedy the limitations due to the scarcity of strong evidence about this topic, future studies should try to clarify predictive value of markers in groups of specific diseases-related subfertility and pay special attention to propaedeutic multivariate models including anti-Müllerian hormone and antral follicle count.
目的
修订激素基础和动态检测以及超声检查作为卵巢储备标志物的作用，以便为不育夫妇提供更好的咨询服务。
方法
回顾关于该主题的出版物，重点关注近期设计良好的文章。
结果
目前可用的卵巢储备检测方法即使对于没有不育主诉的卵巢早衰患者，也没有提供足够的证据来单独被视为理想方法。然而，这些标志物在不育夫妇治疗的初始阶段占据重要地位，可预测不理想的结果，通过差异化的诱导方案可改善这些结果，并减轻过度的心理和经济负担以及不良反应。
结论
为了弥补由于关于该主题的有力证据稀缺而导致的局限性，未来的研究应尝试阐明标志物在特定疾病相关不育群体中的预测价值，并特别关注包括抗苗勒管激素和窦卵泡计数在内的诊断多元模型。
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