Montero Vega M T
Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain.
Allergol Immunopathol (Madr). 2008 May-Jun;36(3):164-75.
In recent years our concept of the non-specific nature of innate immunity has changed following the identification of a network of germline-encoded receptors that recognise with substantial specificity molecular motifs of microorganisms and many other cues produced during tissue injury. Stimulation of these innate sensors by their specific ligands triggers signalling pathways that result in the activation of innate effector mechanisms as well as the priming of naive lymphocytes for the type of response that must be induced. These events culminate in the generation of an immune response appropriately adapted to the damage that has occurred. These new insights into innate immunity herald an entirely new era in the understanding of the molecular events that initiate and drive a host-protective response, changing many concepts about susceptibility to infections and providing greater insight into the underlying inflammatory pathology of other diseases. Targeted manipulation of innate immunity has enormous potential for the development of new vaccines and innovative therapies for the treatment of diseases such as infections, cancer, allergy, autoimmunity and autoinflammatory diseases. This article provides an overview of current trends in the field of innate immunity and its role in the control of infection and disease.
近年来，随着一系列种系编码受体网络的发现，我们对于固有免疫非特异性本质的概念发生了改变，这些受体能够高度特异性地识别微生物的分子基序以及组织损伤过程中产生的许多其他信号。其特异性配体对这些固有传感器的刺激会触发信号通路，从而导致固有效应机制的激活以及初始淋巴细胞针对必须诱导的反应类型的致敏。这些事件最终会产生一种与已发生损伤相适应的免疫反应。这些关于固有免疫的新见解预示着在理解启动和驱动宿主保护反应的分子事件方面开启了一个全新的时代，改变了许多关于感染易感性的概念，并为深入了解其他疾病潜在的炎症病理学提供了更多信息。对固有免疫进行靶向操纵在开发新型疫苗以及治疗感染、癌症、过敏、自身免疫性疾病和自身炎症性疾病等疾病的创新疗法方面具有巨大潜力。本文概述了固有免疫领域的当前趋势及其在控制感染和疾病中的作用。
