Innocent E, Gikonyo N K, Nkunya M H H
Muhimbili University of Health & Allied Sciences, Institute of Traditional Medicine, P.O. Box 65001, Dar es Salaam, Tanzania.
Tanzan J Health Res. 2008 Jan;10(1):50-4. doi: 10.4314/thrb.v10i1.14342.
Long chain aliphatic methyl ketone series of C7-C15 were tested for repellency activity against the malaria transmitting mosquito Anopheles gambiae s.s. All methyl ketones produced a dose dependent (P < 0.001) repellency response with 2-tridecanone giving comparable protection efficacy to DEET at 10% and 1% concentrations. Aliphatic methyl ketones of C7-C10 had lower activity than those of C11-C15. However, within this range compounds with odd carbon atoms (2-undecanone, 2-tridecanone and 2-pentadecanone) were more effective than compounds with even carbon atoms (2-decanone and 2- dodecanone). Comparable repellency activity of 2-tridecanone to DEET show that, it may save as Anopheles gambiae s.s. mosquito repellent.
对碳链长度为C7 - C15的长链脂肪族甲基酮系列进行了针对传播疟疾的冈比亚按蚊的驱避活性测试。所有甲基酮都产生了剂量依赖性（P < 0.001）的驱避反应，其中2 - 十三烷酮在10%和1%浓度下的防护效果与避蚊胺相当。C7 - C10的脂肪族甲基酮活性低于C11 - C15的。然而，在此范围内，具有奇数碳原子的化合物（2 - 十一烷酮、2 - 十三烷酮和2 - 十五烷酮）比具有偶数碳原子的化合物（2 - 癸酮和2 - 十二烷酮）更有效。2 - 十三烷酮与避蚊胺具有相当的驱避活性，表明它可能用作冈比亚按蚊的驱蚊剂。
